Evidence map›Paper›PMID 39285065›Full record

ArticleCardiovascular engineering and technology2024

Development of a High-Fidelity Benchtop Model for Simultaneous Flow, Pressure, and Imaging Assessment of Transarterial Embolization Procedures.

Prateek C Gowda, Robert M Weinstein, Akanksha Bhargava, Janaka Senarathna, Ryan Q Stewart, Pallavi V Ekbote, Mantej Singh, Emily Guan, Serena Banghar, Arvind P Pathak and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular engineering and technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Prateek C GowdaDivision of Interventional Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 7203 Sheikh Zayed Tower, Suite 7, 1800 Orleans Street, Baltimore, MD, 21287, USA.ORCID 0000-0002-2822-7691
Robert M WeinsteinDivision of Interventional Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 7203 Sheikh Zayed Tower, Suite 7, 1800 Orleans Street, Baltimore, MD, 21287, USA.ORCID 0000-0003-4862-0439
Akanksha BhargavaDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0001-8297-6055
Janaka SenarathnaDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0002-5969-0486
Ryan Q StewartDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.
Pallavi V EkboteDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0001-9505-616X
Mantej SinghDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0002-5341-9302
Emily GuanDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.
Serena BangharDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.
Arvind P Pathak *Division of Interventional Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 7203 Sheikh Zayed Tower, Suite 7, 1800 Orleans Street, Baltimore, MD, 21287, USA.ORCID 0000-0002-2068-9445
Clifford R Weiss *Division of Interventional Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 7203 Sheikh Zayed Tower, Suite 7, 1800 Orleans Street, Baltimore, MD, 21287, USA. cweiss@jhmi.edu.ORCID 0000-0003-2180-1731

Funding

Multiscale Image-based Modeling of Antiangiogenic Resistance in Breast CancerR01CA196701 · NCI · JOHNS HOPKINS UNIVERSITY · PI Arvind P Pathak · 2015 to 2026
$3.6M
Next-Gen Oncosurveillance: Wireless Multi-Function Microscopy of In Vivo Brain Cancer DynamicsR01CA237597 · NCI · JOHNS HOPKINS UNIVERSITY · PI Arvind P Pathak · 2020 to 2026
$2.6M
Oxygen-eluting scaffolds for cranial bone regenerationR01DE027957 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI GRAYSON, WARREN L, PATHAK, ARVIND P · 2019 to 2023
$2.4M
Guerbet 09UL2021NCI NIH HHS 5R01CA237597NCI NIH HHS R01 CA196701NCI NIH HHS R01 CA237597NIDCR NIH HHS 5R01DE027957
6 · The paper itself

Abstract

purposeThe development of new endovascular technologies for transarterial embolization has relied on animal studies to validate efficacy before clinical trials are undertaken. Because embolizations in animals and patients are primarily conducted with fluoroscopy alone, local hemodynamic changes are not assessed during testing. However, such hemodynamic metrics could be important indicators of procedure efficacy that could support improved patient outcomes, such as via the determination of procedural endpoints. The purpose of this study is to create a high-fidelity benchtop system for multiparametric (i.e., hemodynamic and imaging) assessment of transarterial embolization procedures.

methodsThe benchtop system consists of a 3D printed, anatomically accurate vascular phantom; a flow loop with a cardiac output simulator; a high-speed video camera; and pressure transducers and flow meters. This system enabled us to vary the heart rate and blood pressure and to simulate clinically relevant hemodynamic states, such as healthy adult, aortic regurgitation, and hypovolemic shock.

resultsWith our radiation-free angiography-mimetic imaging system, we could simultaneously assess gauge pressure and flow values during transarterial embolization. We demonstrated the feasibility of recapitulating the digital subtraction angiography workflow. Finally, we highlighted the utility of this system by characterizing the relationship between an imaging-based metric of procedural endpoint and intravascular flow. We also characterized hemodynamic changes associated with particle embolization within a branch of the hepatic artery and found them to be within reported patient data.

conclusionOur benchtop vascular system was low-cost and reproduced transarterial embolization-related hemodynamic phenomena with high fidelity. We believe that this novel platform enables the characterization of patient physiology, novel catheterization devices, and techniques.

Indexed as

Embolization, TherapeuticHemodynamicsModels, CardiovascularBlood Flow VelocityEquipment DesignHumansModels, AnatomicPredictive Value of TestsPrinting, Three-DimensionalRegional Blood FlowTransducers, PressureVideo Recording3D printingBlood flowHemodynamicsHepatic arteryHepatocellular carcinomaInterventional radiologyIn vitro modelPressureTransarterial embolizationVascular phantom

Identifiers

PMID39285065
PMCPMC13011375

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.