Evidence map›Paper›PMID 39285023›Full record

ArticleLa Radiologia medica2024

Percutaneous thermal segmentectomy for liver malignancies over 3 cm: mid-term oncological performance and predictors of sustained complete response from a multicentric Italian retrospective study.

Pierleone Lucatelli, Bianca Rocco, Renato Argirò, Vittorio Semeraro, Quirino Lai, Elena Bozzi, Sara Crociati, Michele Barone, Alessandro Posa, Carlo Catalano and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in La Radiologia medica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pierleone Lucatelli *Interventional Radiology Unit, Department of Diagnostic Medicine and Radiology, UOC Radiology, Sapienza University of Rome, Rome, Italy.
Bianca Rocco *Interventional Radiology Unit, Department of Diagnostic Medicine and Radiology, UOC Radiology, Sapienza University of Rome, Rome, Italy. biancarocco.br@gmail.com.ORCID http://orcid.org/0000-0002-5073-2846
Renato ArgiròDiagnostic Imaging and Interventional Radiology, University Hospital of Rome Tor Vergata, Rome, Italy.
Vittorio SemeraroSSD Radiologia Interventistica POC SS Annunziata - ASL Taranto, Taranto, Italy.
Quirino LaiGeneral Surgery and Organ Transplantation Unit, Department of Surgery, Sapienza University of Rome, Rome, Italy.
Elena BozziDepartment of Radiology and Interventional Radiology, University of Pisa, Pisa, Italy.
Sara CrociatiDiagnostic Imaging and Interventional Radiology, University Hospital of Rome Tor Vergata, Rome, Italy.
Michele BaroneSSD Radiologia Interventistica POC SS Annunziata - ASL Taranto, Taranto, Italy.
Alessandro PosaFondazione Policlinico Universitario "A. Gemelli" - IRCCS, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia - Area Di Diagnostica per Immagini, UOC Radiologia d'Urgenza ed Interventistica, L.go A Gemelli 8, 00168, Rome, Italy.
Carlo CatalanoInterventional Radiology Unit, Department of Diagnostic Medicine and Radiology, UOC Radiology, Sapienza University of Rome, Rome, Italy.
Laura CrocettiDepartment of Radiology and Interventional Radiology, University of Pisa, Pisa, Italy.
Roberto IezziFondazione Policlinico Universitario "A. Gemelli" - IRCCS, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia - Area Di Diagnostica per Immagini, UOC Radiologia d'Urgenza ed Interventistica, L.go A Gemelli 8, 00168, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPercutaneous thermal segmentectomy is a single-step combination of microwave ablation, performed during arterial occlusion obtained with a balloon micro catheter, followed in the same session by balloon-occluded TACE. The aim of this multicenter retrospective study is to report the mid-term oncological performance of this technique for liver malignancies > 3.0 cm and to identify risk factors for the loss of sustained complete response.

methodsOncological results were evaluated with CT or MRI according to m-RECIST (HCC) and RECISTv1.1 (metastasis/intra-hepatic cholangiocarcinoma, iCC) at 1-month, 3-6-month and then at regular-6-month intervals. To identify predictive variables associated with not achieving or losing complete response two mixed-effects multivariable logistic regression models were constructed.

resultsSixty-three patients (40/23, male/female) with primary liver malignancies (HCC = 49; iCC = 4) and metastasis (n = 10) were treated. Median diameter of target lesion was 4.5 cm (range 3.0-7.0 cm). The median follow-up time was 9.2 months. At one-month follow-up, 79.4% of patients presented with a complete response and the remaining 20.6% were partial responders. At the 3-6-month follow-up, reached by 59 of the initial 63 patients, 83.3% showed a sustained complete response, while 10.2% had a partial response and 8.5% a local recurrence. At the last follow-up, 69.8% of the lesions showed a complete response. The initial diameter of the target lesion ≥ 5.0 cm was the only independent variable associated with the risk of failure in maintaining a complete response at 6 months (OR = 8.58, 95% CI 1.38-53.43; P = 0.02).

conclusionPercutaneous thermal segmentectomy achieves promising oncological results in patients with tumors > 3.0 cm, with tumor dimension ≥ 5.0 cm being the only risk factor associated with the failure of a sustained complete response.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAdultAgedAged, 80 and overCholangiocarcinomaFemaleHumansItalyMagnetic Resonance ImagingMaleMicrowavesMiddle AgedRetrospective StudiesRisk FactorsTomography, X-Ray ComputedBalloon-occluded MWABalloon occluded TACECombined treatmentHepatic tumorInterventional radiology

Identifiers

PMID39285023
PMCPMC11480182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.