Evidence map›Paper›PMID 39285018›Full record

ArticlePediatric radiology2024

Biomarkers of mitochondrial stress and DNA damage during pediatric catheter-directed neuroangiography - a prospective single-center study.

Kaley A Hogarth, Nicholas A Shkumat, Simal Goman, Afsaneh Amirabadi, Suzanne Bickford, Prakash Muthusami, Bairbre L Connolly, Jason T Maynes

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Article in Pediatric radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Kaley A HogarthProgram in Molecular Medicine, SickKids Research Institute, Toronto, ON, Canada. kaley.hogarth@sickkids.ca.ORCID 0000-0001-9784-5082
Nicholas A ShkumatDepartment of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-7929-4587
Simal GomanDepartment of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, ON, Canada.
Afsaneh AmirabadiDepartment of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0001-6324-9776
Suzanne BickfordDepartment of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-5066-9322
Prakash MuthusamiDepartment of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-7062-9571
Bairbre L ConnollyDepartment of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, ON, Canada. bairbre.connolly@sickkids.ca.ORCID 0000-0001-7375-1989
Jason T MaynesProgram in Molecular Medicine, SickKids Research Institute, Toronto, ON, Canada. jason.maynes@sickkids.ca.ORCID 0000-0002-2050-3620

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuroangiography represents a critical diagnostic and therapeutic imaging modality whose associated radiation may be of concern in children. The availability of in vivo radiation damage markers would represent a key advancement for understanding radiation effects and aid in the development of radioprotective strategies.

objectiveDetermine if biomarkers of cellular damage can be detected in the peripheral blood mononuclear cells (PBMC) of children undergoing neuroangiography. MATERIALS AND

methodsProspective single-site study of 27 children. Blood collected pre and post neuroangiography, from which PBMC were isolated and assayed for biomarkers of mitochondrial stress (mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and mitochondrial DNA (mtDNA)) and DNA damage (γH2AX). Dose response of biomarkers vs. radiation dose was analyzed using linear regressions. The cohort was divided into higher (HD) and lower dose (LD) groups and analyzed using linear mixed models and compared using Welch's t-tests.

resultsNo biomarker exhibited a dose-dependent response following radiation (γH2AX: R

conclusionsBiomarkers of mitochondrial stress in PBMC were identified during pediatric neuroangiography and warrant further investigation for radiation biodosimetry. However, isolating radiation-specific effects from those of procedural stress and general anesthesia requires further investigation.

Indexed as

BiomarkersDNA DamageDNA, MitochondrialAdolescentCerebral AngiographyChildChild, PreschoolDose-Response Relationship, RadiationFemaleHumansInfantLeukocytes, MononuclearMaleMembrane Potential, MitochondrialMitochondriaProspective StudiesBiomarkersDNA, MitochondrialReactive Oxygen SpeciesBiomarkersH2A histone family member X (H2AX)Interventional radiologyIonizing radiationMitochondria

Identifiers

PMID39285018

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.