ArticleNature neuroscience2024
Tonic and burst-like locus coeruleus stimulation distinctly shift network activity across the cortical hierarchy.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed.
- Subtyping depression using brain-gastric electrophysiology for early prediction of antidepressant response: a multicentric clinical study.Frontiers in psychiatry · 2026Trial
- Effects of blue light during and after exposure on auditory working memory.Journal of physiological anthropology · 2025Trial
- Modulation of the noradrenergic system using transcranial ultrasonic stimulation targeted to the brainstem locus coeruleus in awake mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Thalamic modulation of cortical linearity across arousal states.Science advances · 2026Article
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- Pharmacological and Physiological Characteristics of Synaptic Transmissions From the Medial Prefrontal Cortex Onto Noradrenergic Neurons and Inhibitory Interneurons in the Mouse Locus Coeruleus.The European journal of neuroscience · 2026Article
- Vulnerability of locus coeruleus connections to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine-related dysfunction on tau and its impact on cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Molecular genetic influences on sustained attention and executive processes and their links with psychopathology in the AFFECT study.Molecular psychiatry · 2026Article
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions.Nature neuroscience · 2026Article
- Inferring norepinephrine dynamics from partial observations reveals the temporal structure of elevations during arousal.bioRxiv : the preprint server for biology · 2026Article
- Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula.Nature communications · 2026Article
- GrimACE: automated, multimodal cage-side assessment of pain and well-being in mice.Lab animal · 2026Article
- Arousal state alters brain network switching and moderates cognitive task performance.bioRxiv : the preprint server for biology · 2026Article
- Burst firing creates an attractor in synaptic weight dynamics.PLoS computational biology · 2026Article
- Neuro-Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis.The Journal of physiology · 2026Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Noradrenaline (NA) release from the locus coeruleus (LC) changes activity and connectivity in neuronal networks across the brain, modulating multiple behavioral states. NA release is mediated by both tonic and burst-like LC activity. However, it is unknown whether the functional changes in target areas depend on these firing patterns. Using optogenetics, photometry, electrophysiology and functional magnetic resonance imaging in mice, we show that tonic and burst-like LC firing patterns elicit brain responses that hinge on their distinct NA release dynamics. During moderate tonic LC activation, NA release engages regions associated with associative processing, while burst-like stimulation biases the brain toward sensory processing. These activation patterns locally couple with increased astrocytic and inhibitory activity and change the brain's topological configuration in line with the hierarchical organization of the cerebral cortex. Together, these findings reveal how the LC-NA system achieves a nuanced regulation of global circuit operations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.