ArticleNature neuroscience2024
Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Trial
- Vagal nerve stimulation induces vascular oscillations and enhances long-term learning.iScience · 2026Article
- Synaptic zinc plasticity shapes adaptive and maladaptive cortical plasticity following cochlear injury.Science advances · 2026Article
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- A brainstem pathway underlying vagal modulation of somatic pain and affective states.Nature neuroscience · 2026Article
- Auricular vagus nerve stimulation drives analgesia via an auricle-brain axis in a mouse model of neuropathic pain.Nature communications · 2026Article
- Colitis-associated gut-vagus-brain signaling integrates tumorigenesis and neuroinflammation: comparative regulation by vagotomy and atropine.Journal of neuroinflammation · 2026Article
- Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Vagus Nerve Stimulation differentially modulates P3b in responders and non-responders: toward a biomarker of therapeutic efficacy.Frontiers in neuroscience · 2026Article
- Modulating autonomic nervous system activity with transcutaneous auricular vagus nerve stimulation in Parkinson's disease: a proof of concept study.Frontiers in neuroscience · 2026Article
- Vagus nerve stimulation: a potential tool to further improve perioperative anesthesia management quality and postoperative recovery?Frontiers in medicine · 2026Review
- Therapeutic potential of vagus nerve stimulation in neurodegenerative diseases: research progress and mechanisms.Frontiers in immunology · 2026Review
- Auricular Transcutaneous Vagus Nerve Stimulation Enhances Post-Stroke Neurological and Cognitive Recovery in Mice by Suppressing Ferroptosis Through α7 Nicotinic Acetylcholine Receptor Activation.CNS neuroscience & therapeutics · 2025Article
- Vagus nerve stimulation as a predictive coding modulator that enhances feedforward over feedback transmission.Frontiers in neural circuits · 2025Review
- Neurotechnology for enhancing human operation of robotic and semi-autonomous systems.Frontiers in robotics and AI · 2025Review
- Speech paired vagus nerve stimulation restores neural sound processing in a rat model of autism.Frontiers in neuroscience · 2025Article
- Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning.Nature neuroscience · 2024Article
- NSF DARE-Transforming modeling in neurorehabilitation: Four threads for catalyzing progress.Journal of neuroengineering and rehabilitation · 2024Review
- Rapid Effects of Vagus Nerve Stimulation on Sensory Processing Through Activation of Neuromodulatory Systems.Frontiers in neuroscience · 2022Review
- Neuromodulator timing regulates adult cortical plasticity via the synaptic eligibility trace.Brain stimulationArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Perception can be refined by experience, up to certain limits. It is unclear whether perceptual limits are absolute or could be partially overcome via enhanced neuromodulation and/or plasticity. Recent studies suggest that peripheral nerve stimulation, specifically vagus nerve stimulation (VNS), can alter neural activity and augment experience-dependent plasticity, although little is known about central mechanisms recruited by VNS. Here we developed an auditory discrimination task for mice implanted with a VNS electrode. VNS applied during behavior gradually improved discrimination abilities beyond the level achieved by training alone. Two-photon imaging revealed VNS induced changes to auditory cortical responses and activated cortically projecting cholinergic axons. Anatomical and optogenetic experiments indicated that VNS can enhance task performance through activation of the central cholinergic system. These results highlight the importance of cholinergic modulation for the efficacy of VNS and may contribute to further refinement of VNS methodology for clinical conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.