Evidence map›Paper›PMID 39284962›Full record

ArticleNature neuroscience2024

Neuroanatomical changes observed over the course of a human pregnancy.

Laura Pritschet, Caitlin M Taylor, Daniela Cossio, Joshua Faskowitz, Tyler Santander, Daniel A Handwerker, Hannah Grotzinger, Evan Layher, Elizabeth R Chrastil, Emily G Jacobs

Abstract read
In one paragraph

Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed.

  1. Trial
  2. Article
  3. Neural circuits for mammalian parental behaviour.Nature reviews. Neuroscience · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
  11. The influence of sex on cognition in psychosis.Schizophrenia research. Cognition · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Maternal experience alters brain-wide representation of infant cries.bioRxiv : the preprint server for biology · 2026
    Article
  19. Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Laura PritschetDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA. laura.pritschet@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-4701-1017
Caitlin M TaylorDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0003-4707-9919
Daniela CossioDepartment of Neurobiology and Behavior, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-1625-8044
Joshua FaskowitzSection on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1814-7206
Tyler SantanderDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA.
Daniel A HandwerkerSection on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-7261-4042
Hannah GrotzingerDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA.
Evan LayherDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA.
Elizabeth R Chrastil *Department of Neurobiology and Behavior, University of California, Irvine, CA, USA. chrastil@uci.edu.ORCID http://orcid.org/0000-0003-2544-0152
Emily G Jacobs *Department of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA. emily.jacobs@psych.ucsb.edu.ORCID http://orcid.org/0000-0003-0001-5096

Funding

Functional MRI Method DevelopmentZIAMH002783 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BANDETTINI, PETER · 2009 to 2025
$38.4M
Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
Impact of ovarian hormone suppression on regional and global brain architecture and cognitionR01AG063843 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JACOBS, EMILY G, PANIZZON, MATTHEW S · 2020 to 2024
$4.8M
Elucidating the role of endocrine aging as a risk factor for Alzheimer's DiseaseK00AG079790 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Laura Pritschet · 2024 to 2026
$228k
Elucidating the role of endocrine aging as a risk factor for Alzheimer's DiseaseF99AG079790 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI PRITSCHET, LAURA · 2022 to 2022
$37k
Intramural NIH HHS ZIA MH002783NIA NIH HHS F99 AG079790NIA NIH HHS K00 AG079790NIA NIH HHS R01 AG063843NIA NIH HHS T32 AG000096U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) ZIAMH002783U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG063843U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) F99AG07979U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) NIH T32 AG00096-40
6 · The paper itself

Abstract

Pregnancy is a period of profound hormonal and physiological changes experienced by millions of women annually, yet the neural changes unfolding in the maternal brain throughout gestation are not well studied in humans. Leveraging precision imaging, we mapped neuroanatomical changes in an individual from preconception through 2 years postpartum. Pronounced decreases in gray matter volume and cortical thickness were evident across the brain, standing in contrast to increases in white matter microstructural integrity, ventricle volume and cerebrospinal fluid, with few regions untouched by the transition to motherhood. This dataset serves as a comprehensive map of the human brain across gestation, providing an open-access resource for the brain imaging community to further explore and understand the maternal brain.

Indexed as

BrainAdultFemaleGray MatterHumansMagnetic Resonance ImagingPregnancyWhite Matter

Identifiers

PMID39284962
PMCPMC11537970

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.