Evidence map›Paper›PMID 39284893›Full record

ArticleScientific reports2024

Human papillomavirus infection of the fallopian tube as a potential risk factor for epithelial ovarian cancer.

Edyta Paradowska, Daria A Haręża, Katarzyna D Kania, Dariusz Jarych, Miłosz Wilczyński, Andrzej Malinowski, Monika Kawecka, Mateusz Nowak, Jacek R Wilczyński

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Edyta Paradowska *Laboratory of Virology, The Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., 93-232, Lodz, Poland. eparadowska@cbm.pan.pl.
Daria A Haręża *Laboratory of Virology, The Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., 93-232, Lodz, Poland.
Katarzyna D KaniaLaboratory of Virology, The Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., 93-232, Lodz, Poland.
Dariusz JarychLaboratory of Virology, The Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., 93-232, Lodz, Poland.
Miłosz WilczyńskiDepartment of Surgical, Endoscopic and Oncological Gynecology, Polish Mother's Health Center Research Institute, Lodz, Poland.
Andrzej MalinowskiDepartment of Surgical, Endoscopic and Oncological Gynecology, Polish Mother's Health Center Research Institute, Lodz, Poland.
Monika KaweckaLaboratory of Virology, The Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., 93-232, Lodz, Poland.
Mateusz NowakDepartment of Gynecology and Obstetrics, Tomaszow Health Center, Tomaszow Mazowiecki, Poland.
Jacek R WilczyńskiDepartment of Gynecology and Obstetrics, Tomaszow Health Center, Tomaszow Mazowiecki, Poland.

Funding

Narodowe Centrum Nauki 2019/33/B/NZ7/02872
6 · The paper itself

Abstract

Human papillomaviruses (HPVs) and herpesviruses are detected in patients with epithelial ovarian cancer (EOC). We sought to analyze the prevalence of HPV's 16 and 18, cytomegalovirus (CMV), and Epstein-Barr virus (EBV) DNA in peripheral blood, ovarian, and fallopian tube (FT) tissue samples collected from 97 EOC patients, including 71 cases of high-grade serous ovarian carcinoma (HGSOC), and from 60 women with other tumors or non-neoplastic gynecological diseases. DNA isolates were analyzed by PCR methods, including droplet digital PCR. The results demonstrate that (1) HPV16 DNA has been detected in one-third of the FT and tumor samples from EOCs; (2) the prevalence and quantity of HPV16 DNA were significantly higher in FT samples from HGSOCs, non-HGSOCs, and ovarian metastases than in those from non-neoplastic diseases; (3) CMV and EBV have been detected in approximately one-seventh of EOC samples. The results suggest that HPV16 might be a potential risk factor for EOC development.

Indexed as

Carcinoma, Ovarian EpithelialFallopian TubesHuman papillomavirus 16Ovarian NeoplasmsPapillomavirus InfectionsAdultAgedCytomegalovirusDNA, ViralFemaleHerpesvirus 4, HumanHumansMiddle AgedRisk FactorsDNA, ViralEpithelial ovarian cancerFallopian tubeHerpesvirusHigh-grade serous ovarian carcinomaPapillomavirus

Identifiers

PMID39284893
PMCPMC11405690

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.