Evidence map›Paper›PMID 39284869›Full record

ArticleCommunications biology2024

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABA

Tommaso Zeppillo, Heba Ali, Sowbarnika Ravichandran, Tamara C Ritter, Sally Wenger, Francisco J López-Murcia, Erinn Gideons, Janetti Signorelli, Michael J Schmeisser, Jens Wiltfang and 4 more

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Neuroligin-2-Dependent Adhesion Defines a Molecular Checkpoint for Inhibitory Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Ethanol Alters the Neurexin Landscape in Human Neuroblastoma Cells.Alcohol, clinical & experimental research · 2026
    Article
  4. Localization and Functional Characterization of MDGA1 in Mouse Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tommaso Zeppillo *Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.
Heba Ali *Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.
Sowbarnika RavichandranInstitute of Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, 55128, Mainz, Germany.
Tamara C RitterInstitute of Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, 55128, Mainz, Germany.ORCID 0000-0003-1821-0316
Sally WengerDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.
Francisco J López-MurciaDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.ORCID 0000-0002-0778-4106
Erinn GideonsDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.
Janetti SignorelliDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.ORCID 0000-0001-9776-2690
Michael J SchmeisserInstitute of Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, 55128, Mainz, Germany.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center of the Georg-August-University Göttingen Mainz, 37075, Göttingen, Germany.ORCID 0000-0003-1492-5330
JeongSeop RheeDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.
Nils BroseDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.
Holger TaschenbergerDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany.ORCID 0000-0003-3186-3231
Dilja Krueger-BurgDepartment of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany. dkruegerburg@uni-mainz.de.ORCID 0000-0001-5597-6287

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroligin-2 (Nlgn2) is a key synaptic adhesion protein at virtually all GABAergic synapses, which recruits GABA

Indexed as

Carrier ProteinsCell Adhesion Molecules, NeuronalMembrane ProteinsMice, KnockoutReceptors, GABA-ASynapsesAnimalsCA1 Region, HippocampalCytosolMaleMiceMice, Inbred C57BLNerve Tissue ProteinsSynaptic TransmissionCarrier ProteinsCell Adhesion Molecules, NeuronalgephyrinMembrane ProteinsNerve Tissue Proteinsneuroligin 2Receptors, GABA-A

Identifiers

PMID39284869
PMCPMC11405390

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.