Evidence map›Paper›PMID 39284837›Full record

ArticleScientific reports2024

Higher sodium in older individuals or after stroke/reperfusion, but not in migraine or Alzheimer's disease - a study in different preclinical models.

Chenchen Xia, Wangde Dai, Juan Carreno, Andrea Rogando, Xiaomeng Wu, Darren Simmons, Natalie Astraea, Nathan F Dalleska, Alfred N Fonteh, Anju Vasudevan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chenchen XiaCognition and Brain Integration Laboratory, Neurosciences Department, Huntington Medical Research Institutes, Pasadena, CA, USA.
Wangde DaiCardiovascular Department, Huntington Medical Research Institutes, Pasadena, CA, USA.
Juan CarrenoCardiovascular Department, Huntington Medical Research Institutes, Pasadena, CA, USA.
Andrea RogandoCognition and Brain Integration Laboratory, Neurosciences Department, Huntington Medical Research Institutes, Pasadena, CA, USA.
Xiaomeng WuAnalytical Biochemistry Core, Huntington Medical Research Institutes, Pasadena, CA, USA.
Darren SimmonsAnalytical Biochemistry Core, Huntington Medical Research Institutes, Pasadena, CA, USA.
Natalie AstraeaAnalytical Biochemistry Core, Huntington Medical Research Institutes, Pasadena, CA, USA.
Nathan F DalleskaWater and Environment Laboratory, California Institute of Technology, Pasadena, CA, USA.
Alfred N FontehBiomarker and Neuro-Disease Mechanism Laboratory, Neurosciences Department, Huntington Medical Research Institutes, Pasadena, CA, USA.
Anju VasudevanAngiogenesis and Brain Development Laboratory, Department of Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, USA.
Xianghong ArakakiCognition and Brain Integration Laboratory, Neurosciences Department, Huntington Medical Research Institutes, Pasadena, CA, USA. xianghong.arakaki@hmri.org.
Robert A KlonerCardiovascular Department, Huntington Medical Research Institutes, Pasadena, CA, USA.

Funding

Dysfunction of Sodium Homeostasis in MigraineR01NS072497 · NINDS · HUNTINGTON MEDICAL RESEARCH INSTITUTES · PI ARAKAKI, XIANGHONG, GRANT, SAMUEL COLLES · 2011 to 2023
$4.8M
NIH/NINDS R01NS072497NINDS NIH HHS R01 NS072497
6 · The paper itself

Abstract

Sodium serves as one of the primary cations in the central nervous system, playing a crucial role in maintaining normal brain function. In this study, we investigated alterations in sodium concentrations in the brain and/or cerebrospinal fluid across multiple models, including an aging model, a stroke model, a nitroglycerin (NTG)-induced rat migraine model, a familial hemiplegic migraine type 2 (FHM2) mouse model, and a transgenic mouse model of Alzheimer's disease (AD). Our results reveal that older rats exhibited higher sodium concentrations in cerebrospinal fluid (CSF), plasma, and various brain regions compared to their younger counterparts. Additionally, findings from the stroke model demonstrated a significant increase in sodium in the ischemic/reperfused region, accompanied by a decrease in potassium and an elevated sodium/potassium ratio. However, we did not detect significant changes in sodium in the NTG-induced rat migraine model or the FHM2 mouse model. Furthermore, AD transgenic mice showed no significant differences in sodium levels compared to wild-type mice in CSF, plasma, or the hippocampus. These results underscore the nuanced regulation of sodium homeostasis in various neurological conditions and aging, providing valuable insights into potential mechanisms underlying these alterations.

Indexed as

AgingAlzheimer DiseaseDisease Models, AnimalMice, TransgenicMigraine DisordersSodiumStrokeAnimalsBrainHumansMaleMiceMigraine with AuraNitroglycerinRatsRats, Sprague-DawleyNitroglycerinSodiumAgingCSFNa+/K+-ATPaseNeurological diseaseSodiumStroke

Identifiers

PMID39284837
PMCPMC11405707

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.