ArticleAJNR. American journal of neuroradiology2025
Vestibular Schwannoma-Related Increased Labyrinthine Postgadolinium 3D-FLAIR Signal Intensity and Association with Hearing Impairment.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Unique Natural History of Very Small Vestibular Schwannoma Substantiates Size Threshold Surveillance.The Laryngoscope · 2026Article
- [Audiological findings and analysis in 93 cases of unilateral vestibular schwannoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Article
- Advances in imaging modalities and tumor classification for vestibular schwannomas.Journal of neuro-oncology · 2026Review
- Multi-sequence MRI signal intensity ratios as candidate imaging correlates for audiovestibular dysfunction in vestibular schwannoma.Frontiers in neurology · 2026Observational
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Authors and funding
9 authors.
Funding
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Abstract
background and purposeVestibular schwannomas (VSs) are benign neurogenic tumors commonly associated with progressive unilateral hearing loss, tinnitus, and vestibular symptoms. Growing evidence links signal changes in the VS-adjacent labyrinth with sensorineural hearing loss. This study seeks to quantify the association of labyrinthine signal on postgadolinium 3D-FLAIR imaging correlates with hearing loss and to evaluate potential longitudinal changes over time. MATERIALS AND
methodsSelected patients were identified from a prospectively maintained VS registry. Mean signal intensity ratios of the bilateral labyrinth and pons were measured on 3D-FLAIR postgadolinium MRI. Correlations with paired audiometric data, including pure tone average (PTA), word recognition score (WRS), and American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) hearing class within 1 year, were evaluated.
resultsOne hundred twenty-five studies obtained from 2015 to 2022 among 66 patients undergoing observational management for sporadic VS were analyzed. Increased signal intensity was noted in the VS-affected labyrinth/contralateral labyrinth (mean ratio 1.56, SD 0.58). Increased signal intensity was associated with increased PTA on both labyrinthine (correlation coefficient [CC] 0.20,
conclusionsIncreased 3D-FLAIR postgadolinium labyrinthine signal is associated with sensorineural hearing loss; however, its relationship with hearing trajectory remains unclear. Overall findings suggest that while postgadolinium 3D-FLAIR techniques are sensitive to inner ear involvement associated with VS, the driving mechanism and their temporal relationships with labyrinthine signal intensity and hearing impairment remain unknown.
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