Evidence map›Paper›PMID 39284534›Full record

ArticleThe Journal of nutritional biochemistry2025

HFD feeding for seven months abolishes STING disruption-driven but not female sex-based protection against hepatic steatosis and inflammation in mice.

Xinlei Guo, Honggui Li, Bilian Zhu, Xiaoxiao Wang, Qian Xu, Eduardo Aquino, Minji Koo, Qingsheng Li, James Cai, Shannon Glaser and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutritional biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xinlei GuoDepartment of Nutrition, Texas A&M University, College Station, Texas, USA.
Honggui LiDepartment of Nutrition, Texas A&M University, College Station, Texas, USA.
Bilian ZhuDepartment of Nutrition, Texas A&M University, College Station, Texas, USA.
Xiaoxiao WangDepartment of Nutrition, Texas A&M University, College Station, Texas, USA.
Qian XuDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.
Eduardo AquinoDepartment of Nutrition, Texas A&M University, College Station, Texas, USA.
Minji KooDepartment of Nutrition, Texas A&M University, College Station, Texas, USA.
Qingsheng LiNebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
James CaiDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.
Shannon GlaserDepartment of Medical Physiology, Texas A&M University College of Medicine, Byran, Texas, USA. Electronic address: sglaser@tamu.edu.
Chaodong WuDepartment of Nutrition, Texas A&M University, College Station, Texas, USA. Electronic address: chaodong.wu@ag.tamu.edu.

Funding

Role of STING in Cholestatic Liver InjuryR01DK135881 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Burcin Ekser, Shannon Stroud Glaser · 2023 to 2026
$1.9M
ADK Regulation of Fat Metabolism and Insulin SensitivityR01DK124854 · NIDDK · TEXAS A&M AGRILIFE RESEARCH · PI WU, CHAODONG · 2020 to 2023
$1.8M
NIDDK NIH HHS R01 DK124854NIDDK NIH HHS R01 DK135881
6 · The paper itself

Abstract

Stimulator of interferon genes (STING) is positively correlated with the degrees of liver inflammation in human metabolic dysfunction-associated steatotic liver disease (MASLD). In addition, STING disruption alleviates MASLD in mice fed a high-fat diet (HFD) for 3 months (3-m-HFD). Here we investigated the role of the duration of dietary feeding in regulating MASLD in mice and explored the involvement of STING in sex differences in MASLD. Both male and female STING-disrupted (STING

Indexed as

Diet, High-FatInflammationMembrane ProteinsMice, Inbred C57BLAnimalsFatty LiverFemaleLiverMaleMiceOvariectomySex FactorsSTING ProteinMembrane ProteinsSting1 protein, mouseSTING Proteinliver inflammationMASLDObesitySex differencesSTING

Identifiers

PMID39284534
PMCPMC11620956

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.