Evidence map›Paper›PMID 39284455›Full record

ArticleBioorganic & medicinal chemistry letters2024

Stability studies of β-Amino- and β-Hydroxy difluoromethyl ketones in rat serum and rat liver microsomes.

Baharul Islam, Katherine E Kreusel, Suresh P Sulochana, Alex L Nguyen, Munia F Sowaileh, Hari R Khatri, Madeline H Griffin, Demetra A Leara, David A Colby

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Baharul IslamDepartment of BioMolecular Sciences, University of Mississippi, University, MS 38677, USA.
Katherine E KreuselDepartment of BioMolecular Sciences, University of Mississippi, University, MS 38677, USA.
Suresh P SulochanaDepartment of Pharmaceutics and Drug Delivery, University of Mississippi, University, MS 38677, USA.
Alex L NguyenDepartment of BioMolecular Sciences, University of Mississippi, University, MS 38677, USA.
Munia F SowailehDepartment of BioMolecular Sciences, University of Mississippi, University, MS 38677, USA.
Hari R KhatriDepartment of BioMolecular Sciences, University of Mississippi, University, MS 38677, USA.
Madeline H GriffinDepartment of BioMolecular Sciences, University of Mississippi, University, MS 38677, USA.
Demetra A LearaDepartment of BioMolecular Sciences, University of Mississippi, University, MS 38677, USA.
David A ColbyDepartment of BioMolecular Sciences, University of Mississippi, University, MS 38677, USA. Electronic address: dacolby@olemiss.edu.

Funding

Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026
$17.9M
Pilot Project ProgramP30GM122733 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI WILLETT, KRISTINE L · 2018 to 2022
$5.3M
Developing Biased Agonists of the GABA-B ReceptorR15DA046795 · NIDA · UNIVERSITY OF MISSISSIPPI · PI COLBY, DAVID A · 2018 to 2018
$418k
NIDA NIH HHS R15 DA046795NIGMS NIH HHS P20 GM130460NIGMS NIH HHS P30 GM122733
6 · The paper itself

Abstract

Although difluoromethyl ketones are used as tools in chemical biology and leads in drug discovery, the metabolic stability of these compounds is generally uncharacterized and must be inferred from in vivo pharmacological assays. In order to address this gap which impedes their wider use, we have synthesized and performed metabolic stability studies for thirty-nine β-amino and β-hydroxy difluoromethyl ketones. These investigations provide structure-stability relationships of the difluoromethyl ketones following incubation with rodent serum and liver microsomes.

Indexed as

KetonesMicrosomes, LiverAnimalsMolecular StructureRatsStructure-Activity RelationshipKetonesDifluoromethyl ketonesDrug discoveryDrug stabilityFluorine chemistry

Identifiers

PMID39284455
PMCPMC11490360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.