Evidence map›Paper›PMID 39284179›Full record

ArticleJMIR research protocols2024

Family Support Protocol for Adolescent Internalizing Disorders: Protocol for a Pre-Post Quantitative Treatment Development Study.

Aaron Hogue, Molly Bobek, Nicole P Porter, Alexandra MacLean, Craig E Henderson, Amanda Jensen-Doss, Gary M Diamond, Michael A Southam-Gerow, Jill Ehrenreich-May

Registry-linked trialAbstract read
In one paragraph

Article in JMIR research protocols, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06413979 (Testing the Feasibility of a Family-based Adjunctive Treatment Protocol for Targeting Co-Occurring Internalizing Disorders Among Adolescents With SUD), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06413979 narecruitingnot on this mapstarted 2025, after this paper: background citation

Testing the Feasibility of a Family-based Adjunctive Treatment Protocol for Targeting Co-Occurring Internalizing Disorders Among Adolescents With SUD

TypeinterventionalSponsorThe National Center on Addiction and Substance Abuse at Columbia UniversityRan2025 to 2027Enrolled60ConditionsInternalizing Disorders, Substance Use DisordersArmsFamily Support Protocol for Adolescent Internalizing Disorders (Fam-AID)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Evidence Base on Outpatient Behavioral Treatments for Adolescent Substance Use, Update 2018-2023: Current Status, Best Practices, and Opportunities for Advancing the Science.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aaron HogueFamily and Adolescent Clinical Technology & Science, Partnership to End Addiction, New York, NY, United States.ORCID 0000-0001-8365-9545
Molly BobekFamily and Adolescent Clinical Technology & Science, Partnership to End Addiction, New York, NY, United States.ORCID 0009-0007-4961-8652
Nicole P PorterFamily and Adolescent Clinical Technology & Science, Partnership to End Addiction, New York, NY, United States.ORCID 0000-0001-6149-9501
Alexandra MacLeanFamily and Adolescent Clinical Technology & Science, Partnership to End Addiction, New York, NY, United States.ORCID 0009-0004-1656-2427
Craig E HendersonDepartment of Psychology, Sam Houston State University, Huntsville, TX, United States.ORCID 0000-0003-2779-8879
Amanda Jensen-DossDepartment of Psychology, University of Miami, Coral Gables, FL, United States.ORCID 0000-0002-1817-6122
Gary M DiamondDepartment of Psychology, Ben-Gurion University of the Negev, Be-er Sheva, Israel.ORCID 0000-0003-0781-1810
Michael A Southam-GerowDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, United States.ORCID 0000-0002-4545-6752
Jill Ehrenreich-MayDepartment of Psychology, University of Miami, Coral Gables, FL, United States.ORCID 0000-0001-7436-5393

Funding

Family-based Recovery Support Service Network for Youth OUDR24DA051946 · NIDA · PARTNERSHIP TO END ADDICTION · PI HOGUE, AARON · 2020 to 2025
$4.6M
Testing the Feasibility of a Family-based Adjunctive Treatment Protocol for Targeting Co-Occurring Internalizing Disorders among Adolescents with SUDR34DA056026 · NIDA · PARTNERSHIP TO END ADDICTION · PI Aaron Hogue · 2024 to 2026
$730k
NIDA NIH HHS R24 DA051946NIDA NIH HHS R34 DA056026
6 · The paper itself

Abstract

backgroundInternalizing disorders (IDs), primarily depression and anxiety, are highly prevalent among adolescents receiving community-based treatment for substance use disorders (SUDs). For such clients, interventions that do not holistically address both SUDs and IDs are less effective.

objectiveThis pilot treatment development study aims to develop and test a modular treatment protocol for addressing cooccurring IDs among adolescents (aged 13 to 18 years) enrolled in routine care for substance use problems: Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID). As an adjunctive protocol, Fam-AID will not require clinicians to markedly alter existing base practices for SUD. It will be anchored by 3 evidence-based foundations for treating cooccurring adolescent IDs: family engagement techniques, transdiagnostic individual cognitive behavioral therapy techniques, and family psychoeducation and safety planning.

methodsThis quasi-experimental study will proceed in 2 stages. The pilot stage will use rapid-cycle prototyping methods in collaboration with end-user stakeholders to draft protocol delivery and fidelity guidelines adapted from existing resources, solicit provider and client input on protocol content and delivery via cognitive interviewing, and pilot prototype components on 4 to 6 cases. The second stage will be an interrupted time series study for 60 comorbid SUD+ID cases across 2 sites serving diverse adolescents: 30 will receive treatment as usual (TAU); following clinician training in the protocol, 30 new cases will receive TAU enhanced by Fam-AID. For aim 1, the focus is on evaluating the acceptability of the Fam-AID protocol through therapist and client interviews as well as assessing fidelity benchmarks using therapist- and observer-reported protocol fidelity data. For aim 2, the plan is to compare the effects of TAU only cases versus TAU+Fam-AID cases on family treatment attendance and on adolescent ID and substance use symptoms, with measurements taken at baseline and at 3-month and 6-month follow-ups.

resultsStudy recruitment will begin in April 2025.

conclusionsWe anticipate that Fam-AID will contain 5 treatment modules that can be delivered in any sequence to meet client needs: family engagement of primary supports in treatment planning and services; relational reframing of family constraints, resiliencies, and social capital connected to the adolescent's ID symptoms; functional analysis of the adolescent's ID symptoms and related behaviors; cognitive behavioral therapy to address the adolescent's ID symptoms and functional needs, featuring 3 core techniques (emotion acceptance, emotional exposure, and behavioral activation) to address negative affect and emotional dysregulation; and family psychoeducation and safety planning focused on education about comorbid SUD+ID and prevention of adolescent self-harm. If the abovementioned modules are found to be feasible and effective, Fam-AID will offer a set of pragmatic interventions to SUD clinicians for treating cooccurring IDs in adolescent clients.

trial registrationClinicalTrials.gov NCT06413979; https://www.clinicaltrials.gov/study/NCT06413979. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/64332.

Indexed as

Family TherapyAdolescentCognitive Behavioral TherapyFamily SupportFemaleHumansMalePilot ProjectsSubstance-Related Disordersadjunctive treatmentadolescent anxiety and depressionadolescent substance usecooccurring disordersfamily-based interventionsusual care

Identifiers

PMID39284179
PMCPMC11443177

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.