Evidence map›Paper›PMID 39283578›Full record

ArticleAnnals of surgical oncology2025

Minimally Invasive Surgery: Is It a Risk Factor for Postoperative Peritoneal Metastasis in pT4 Colon Cancer?

Sun Jung Kim, Min Young Park, Seung Yoon Yang, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Byung Soh Min

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Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sun Jung KimDepartment of Surgery, Ajou University Hospital, Suwon-si, Gyeonggi-do, Republic of Korea.
Min Young ParkDivision of Colorectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
Seung Yoon YangDivision of Colorectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
Yoon Dae HanDivision of Colorectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
Min Soo ChoDivision of Colorectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
Hyuk HurDivision of Colorectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kang Young LeeDivision of Colorectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
Byung Soh MinDivision of Colorectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. bsmin@yuhs.ac.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerforming laparoscopic surgery for T4 colon cancer remains controversial because of concerns about whether its oncologic outcomes are comparable to those of open surgery, and postoperative peritoneal metastasis (PM) has been reported to occur more frequently in laparoscopic colectomy for T4 colon cancer. We investigated whether minimally invasive surgery (MIS) demonstrated a higher PM rate than open surgery and analyzed the risk factors for PM in pT4 colon cancer.

methodsThis study included 392 patients with pT4 colon cancer who underwent curative surgery at a referral hospital between January 2000 and December 2018. Patients with previous neoadjuvant therapy, synchronous malignancy, metastasis, or those who underwent hyperthermic intraperitoneal chemotherapy were excluded.

resultsThe MIS group had fewer high-risk clinical features, such as tumors too large for endoscope admission or complications like perforation and fistula. The group also exhibited shorter operative time, intraoperative blood loss, multivisceral resection, hospital stay, fewer postoperative complications, smaller tumor size, lower pT4b ratio, and higher pN+ rates. Multivariate analysis revealed that high-risk clinical features, MIS, pT4b, pN+, tumor size < 5 cm, high histological grade, lymphovascular invasion, and postoperative complications were significant risk factors for PM. During the median 59-month follow-up, the 5-year cumulative incidence of PM was elevated in the MIS group (17.5% vs. 8.2%; P = 0.057). No significant differences were observed in the 5-year overall and disease-free survival rates.

conclusionsMinimally invasive surgery increases the risk of postoperative PM in patients with pT4 colon cancer. Surgeons may require thorough tumor staging and radical resection to prevent PM.

Indexed as

Colonic NeoplasmsLaparoscopyPeritoneal NeoplasmsPostoperative ComplicationsAdultAgedColectomyFemaleFollow-Up StudiesHumansMaleMiddle AgedMinimally Invasive Surgical ProceduresNeoplasm StagingPrognosisRetrospective StudiesColon cancerMinimally invasive surgeryPeritoneal metastasisT4 cancer

Identifiers

PMID39283578

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.