ArticleThe international journal of cardiovascular imaging2024
Analysis of myocardial T1, T2, and T2* values by age, sex, and cardiac segments in normal population: a prospective study.
Article in The international journal of cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Native myocardial T1 reference values in a tunisian cohort using MOLLI and SMART1Map.Scientific reports · 2026Article
- Myocardial T2 Star (T2*) in a Large Healthy Population: Correction Factors for a Segmental Approach Using Commercially Available Software in the Current MRI Era.Tomography (Ann Arbor, Mich.) · 2026Article
- Evaluation of myocardial fibrosis and cardiac function in fibrotic lung diseases: a prospective study.Scientific reports · 2025Article
- Optimizing synthetic hematocrit for cardiac MRI: a multivariable model calibrated with standardized venous sampling.The international journal of cardiovascular imaging · 2025Article
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Authors and funding
4 authors.
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Abstract
This study examines myocardial T1, T2, and T2* values in a sizable cohort of healthy volunteers, analyzing variations by age, sex, and cardiac segments. It offers a novel approach to defining normal parametric mapping boundaries and represents the first comprehensive study of its kind in Turkey. Our prospective study was conducted between August 2021 and August 2022. Healthy volunteers aged 20-80 were grouped, with at least eight females and eight males per decade. Cardiac MRI examination measured T1 and T2 times in 16 left ventricle segments using parametric mapping techniques on a 1.5 Tesla MRI device. T2* mapping was also performed on the mid-section interventricular septum. The data analysis considered the impact of age, sex, and segments. One hundred eighteen cases were included in the study. Female volunteers observed significantly higher T1, T2, and T2* values than male volunteers. For the T2* and T1 times, significantly lower values were detected in women over 50 than those under 50. It was observed that the Midventricular approach (middle section) gave closer results than the Midventricular Septal approach (septal region of middle section) in predicting Global times. We present the normal reference ranges for cardiac T1, T2, and T2* times in a large cohort of healthy volunteers with homogeneous sex and age distribution. Sex was the most influential factor in our study. Therefore, we suggest using separate reference values for males, and females above and below 50 years old, instead of the standard reference intervals that do not account for specified sex in current guidelines.
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