Evidence map›Paper›PMID 39283420›Full record

ArticleAdvances in experimental medicine and biology2024

Ethanol Inhalation as a Method to Denature the Spike Protein of SARS-CoV-2.

Thomas J Manning, Teighlor Livingston, Capri Persaud, Akshil Patel, Madelyn Adair, Taylor Taylor, Paige Bland

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas J ManningChemistry Department, Valdosta State University, Valdosta, GA, 31698, USA. tmanning@valdosta.edu.
Teighlor LivingstonPhiladelphia College of Osteopathic Medicine, Moultrie, GA, USA.
Capri PersaudChemistry Department, Valdosta State University, Valdosta, GA, 31698, USA.
Akshil PatelChemistry Department, Valdosta State University, Valdosta, GA, 31698, USA.
Madelyn AdairChemistry Department, Valdosta State University, Valdosta, GA, 31698, USA.
Taylor TaylorChemistry Department, Valdosta State University, Valdosta, GA, 31698, USA.
Paige BlandChemistry Department, Valdosta State University, Valdosta, GA, 31698, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 virus caused the 2019 COVID pandemic by infecting almost eight hundred million people worldwide. Because it was a new viral infection, there were no vaccines or small molecule medications that could prevent or treat the disease.  This chapter provides some details for an obscure treatment for COVID-19, that has decades of anti-viral activity data both in vitro and in vivo in the literature. The medicinal molecules are compared to other small molecules that were identified as possible medications for COVID-19.  We developed a computational method that ranks small molecules and their ability to penetrate mucus in the lungs of a COVID-19 patient. Our focus is ethanol as a COVID-19 treatment. The results discussed here are based on Lipinski Rules and QSAR computational methods as well as in vitro and in vivo data. These parameters indicate that ethanol should be a strong candidate for future evaluations.

Indexed as

COVID-19 Drug TreatmentEthanolSARS-CoV-2Spike Glycoprotein, CoronavirusAdministration, InhalationAnimalsAntiviral AgentsCOVID-19HumansAntiviral AgentsEthanolSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Corona virusCOVID-19DenatureEthanolInhalationSARS-CoV-2Spike protein

Identifiers

PMID39283420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.