Evidence map›Paper›PMID 39283358›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025

The role of Perifoveal Arteriolar Tortuosity in Optical Coherence Tomography Angiography (OCTA) images as an early indicator of hypertensive retinopathy.

James Park, Charu Vyas, Onur İnam, Henry W Zhou, Zachary E Snow, Rabia Karani, Dvir Koenigstein, Tongalp H Tezel

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

James ParkDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0082-3416
Charu VyasDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7943-1684
Onur İnamDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4726-1190
Henry W ZhouDepartment of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4060-8187
Zachary E SnowDepartment of Ophthalmology, University of Miami Health System, Bascom Palmer Eye Institute, Miami, FL, USA.ORCID http://orcid.org/0000-0002-8843-9514
Rabia KaraniDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8429-4410
Dvir KoenigsteinDepartment of Ophthalmology, BronxCare Health System, Bronx, NY, USA.ORCID http://orcid.org/0000-0002-6027-7074
Tongalp H TezelDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA. tht2115@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-8416-0452

Funding

Foley Research Fund, New York, NY Foley Research Fund, New York, NYResearch to Prevent Blindness Research to Prevent Blindness
6 · The paper itself

Abstract

purposeTo assess the value of increased perifoveal retinal vascular tortuosity in optical coherence tomography angiography (OCTA) images as a biomarker of early hypertensive retinopathy and compare its clinical sensitivity and accuracy with traditional morphological changes used for Scheie classification.

methodsOCTA images of 81 eyes (40 eyes from 20 hypertensive subjects and 41 eyes from 21 control subjects) were obtained retrospectively. Hypertensive retinopathy changes in randomized eyes were graded according to the Scheie classification, and perifoveal vessels were traced in a masked fashion. Tortuosity values of the perifoveal vessels were then calculated along with interobserver agreement in determining the morphometric values.

resultsThere were no differences in perifoveal venular tortuosity between the hypertensive and control groups (Mean = 1.13 ± 0.04 vs. 1.13 ± 0.03), but significant differences existed for arterioles (Mean = 1.14 ± 0.05 vs. 1.11 ± 0.04). Tortuosity measurements demonstrated a significant interobserver agreement (p < 0.001), while Scheie ratings had a poor interobserver agreement (p = 0.735). There was a significant difference in Scheie classification between the hypertensive and control groups (Mean = 1.06 ± 0.54 vs. 0.50 ± 0.43, p = 0.005).

conclusionsOCTA-based perifoveal retinal arteriolar tortuosity may be a potential reliable biomarker with certain advantages for detecting early hypertensive retinopathy than morphological changes used for the Scheie classification. This may have broad applications and establish important parameters in utilizing OCTA for screening protocols, considering the importance of early detection of systemic hypertension.

Indexed as

Fluorescein AngiographyFovea CentralisHypertensive RetinopathyRetinal ArteryTomography, Optical CoherenceAdultAgedArteriolesEarly DiagnosisFemaleFundus OculiHumansMaleMiddle AgedRetinal VesselsRetrospective StudiesHypertensionHypertensive retinopathyOptical coherence tomography angiographyScheie classificationTortuosity

Identifiers

PMID39283358

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.