Evidence map›Paper›PMID 39283344›Full record

Trial reportStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2025

Comparison of liposomal gel with and without chamomile to prevent radiation dermatitis in breast cancer patients: a randomized controlled trial.

Amanda Gomes de Meneses, Elaine Barros Ferreira, Larissa Aparecida Corrêa Vieira, Priscila de Souza Maggi Bontempo, Eliete Neves Silva Guerra, Marcia Aparecida Ciol, Paula Elaine Diniz Dos Reis

Abstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amanda Gomes de MenesesInterdisciplinary Laboratory of Research Applied to Clinical Practice in Oncology, Faculty of Health Sciences, University of Brasilia, DF 70910-900, Brasília, Brazil.ORCID 0000-0002-8658-7505
Elaine Barros FerreiraInterdisciplinary Laboratory of Research Applied to Clinical Practice in Oncology, Faculty of Health Sciences, University of Brasilia, DF 70910-900, Brasília, Brazil.ORCID 0000-0003-0428-834X
Larissa Aparecida Corrêa VieiraInterdisciplinary Laboratory of Research Applied to Clinical Practice in Oncology, Faculty of Health Sciences, University of Brasilia, DF 70910-900, Brasília, Brazil.ORCID 0000-0002-0998-6959
Priscila de Souza Maggi BontempoInterdisciplinary Laboratory of Research Applied to Clinical Practice in Oncology, Faculty of Health Sciences, University of Brasilia, DF 70910-900, Brasília, Brazil.ORCID 0000-0002-7120-1059
Eliete Neves Silva GuerraLaboratory of Oral Histopathology, Faculty of Health Sciences, University of Brasilia, Brasília, Brazil.ORCID 0000-0002-7622-1550
Marcia Aparecida CiolSchool of Medicine, Department of Rehabilitation Medicine, University of Washington, Seattle, USA.ORCID 0000-0001-6406-4706
Paula Elaine Diniz Dos ReisInterdisciplinary Laboratory of Research Applied to Clinical Practice in Oncology, Faculty of Health Sciences, University of Brasilia, DF 70910-900, Brasília, Brazil. pauladiniz@unb.br.ORCID 0000-0002-9782-3366

Funding

Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil ScholarshipNational Council for Scientific and Technological Development 432802/2016-9
6 · The paper itself

Abstract

purposeTo compare a liposomal gel with and without chamomile extract for the prevention of radiation dermatitis in breast cancer patients undergoing radiotherapy.

methodsThis study was a double-blind randomized clinical trial. A total of 100 participants undergoing radiotherapy for breast cancer were recruited. The primary outcome was the occurrence of dry desquamation. Cumulative dose of ionizing radiation at the first occurrence of dry desquamation, occurrence of erythema, moist desquamation, global radiation dermatitis, and any signs and symptoms self-reported by participants were secondary outcomes.

resultsDry desquamation occurred in 6.0% of the participants using chamomile liposomal gel and 12.2% of those using liposomal gel (p = 0.32). The mean cumulative dose of ionizing radiation for the first occurrence of dry desquamation was 45.1 Gy in the chamomile liposomal gel group and 43.7 Gy in the liposomal gel group. There were no differences between the two gels in the occurrence of erythema, dry desquamation, moist desquamation, and radiation dermatitis compared to liposomal gel. There was a lower proportion of reported symptoms in the chamomile liposomal gel group compared to liposomal gel group in the first 3 weeks of radiation, especially for itching (p = 0.05).

conclusionNo statistically significant differences between the two gels were found in radiation dermatitis occurrence and dose at first occurrence. Comparing to the literature, it seems that both interventions may be effective, which might explain the lack of statistical difference between the groups.

Indexed as

Breast NeoplasmsChamomilePhytotherapyPlant ExtractsRadiodermatitisAdultAgedDouble-Blind MethodFemaleGelsHumansLiposomesMiddle AgedTreatment OutcomeGelsLiposomesPlant ExtractsDry desquamationMatricariaNursing CareRadiotherapySkin Care

Identifiers

PMID39283344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.