ArticleArtificial organs2025
Outcomes after SynCardia® temporary total artificial heart implantation: A 20-year single-center experience in 196 patients.
Article in Artificial organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Beyond Continuous-Flow: The Next Wave of Fully Implantable LVADs and Total Artificial Hearts.Current heart failure reports · 2026Review
- The repaired man or the man with extras: medical human-cyborgs.Frontiers in digital health · 2026Article
- The Total Artificial Heart: A Historical Perspective.Journal of clinical medicine · 2025Article
- A fully implantable sensorized artificial urinary bladder to restore continence and fullness monitoring.APL bioengineering · 2025Article
- Outcomes after SynCardia® temporary total artificial heart implantation: A 20-year single-center experience in 196 patients.Artificial organs · 2025Article
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Authors and funding
11 authors.
Funding
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Abstract
backgroundThe SynCardia® temporary total artificial heart (TAH) serves as a mechanical circulatory support device for patients suffering from irreversible biventricular failure.
methodsThis retrospective study analyzed 196 consecutive patients who underwent TAH implantation at our center from 2001 to 2021. We assessed survival rates and all-cause mortality during TAH support, including survival post-heart transplantation.
resultsThe median age of patients was 55 years, with 88% being male. The primary diagnoses included cardiomyopathy (43.9%), acute myocardial infarction (26.5%), and postcardiotomy heart failure (15.5%). At implantation, 87.2% of patients were classified as INTERMACS Profile 1. The median duration of support was 96 days (IQR: 23-227). Survival rates at 1, 6, and 12 months were 72%, 41%, and 34%, respectively. Postoperative rethoracotomy was necessary in 44.4% of patients; 39.3% experienced neurological events and 24.6% developed gastrointestinal bleeding. Overall, 64.8% of patients died while on support, primarily due to multiple organ failure (55.9%). Factors such as older age, higher bilirubin levels, postcardiotomy and specific underlying diagnoses were independent predictors of mortality during TAH support. On a positive note, 35.2% of patients underwent successful heart transplants, with 1-, 5-, and 10-year posttransplant survival rates of 65%, 58%, and 51%, respectively.
conclusionsWhile high mortality rates persist among patients with biventricular failure, the SynCardia® TAH offers a viable interim solution for critically ill patients, particularly those who can be successfully bridged to heart transplantation.
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