ArticleJournal of studies on alcohol and drugs2025
Male Predominance in West Virginia Unintentional Overdose Deaths Is Influenced by Alcohol and Co-Intoxicants.
Article in Journal of studies on alcohol and drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe purpose of this study was to examine sex differences in overdose (OD) mortality based on substances involved.
methodWe conducted a retrospective database analysis of West Virginia OD decedents (12,666 unintentional OD deaths, 2005-early 2023). Exposures were substances judged to contribute to death. The main outcome measure was determination of male to female death ratios with varying co-intoxicant involvement, particularly related to alcohol and fentanyl. Secondary outcomes included associations of fentanyl concentrations with alcohol concentrations and male sex, including fentanyl and inactive metabolite norfentanyl concentration variability between sexes.
resultsAlcohol co-intoxication in OD deaths was associated with higher male:female death ratios, from 2.0 (alcohol absent) to 3.3 (alcohol present). There was a greater increase over time in alcohol involvement in recent deaths involving females compared with males (relative increases of 52% vs. 6%, respectively). Male:female ratios with alcohol and fentanyl co-involvement ranged from 5.9:1 (only two drugs involved) to 2.4:1 (≥5 substances), with females significantly more likely to have multiple substances contributing to death. Overall, males had statistically significantly larger fentanyl to norfentanyl median concentration ratios compared with females (8.8 vs. 6.9, respectively). Multivariable analyses found that alcohol presence was associated with a statistically significant 22% reduction in predicted fentanyl concentrations.
conclusionsMale:female ratios in unintentional OD deaths were higher with greater alcohol involvement and lower with fewer co-intoxicants. Fentanyl and norfentanyl concentration differences by sex were observed. It is important to determine possible contributors to sex differences in OD death rates to better target prevention and treatment initiatives.
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