ArticleJournal of cosmetic dermatology2025
Energy-Based Device Management of Nodular Reaction Following Poly-D, L-Lactic Acid Injection for Tear Trough Rejuvenation.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Safety of Extracorporeal Shock Wave Therapy and 1064 nm Nd:YAG Laser in Managing Nodules and Edema Following Cosmetic Injections: A Case Series and Systematic Literature Review.Journal of cosmetic dermatology · 2026Pooled it
- Efficacy and Safety of Poly-l-Lactic Acid for Correction of Midfacial Volume Loss and Contour Defects: A Prospective, Multicenter, Randomized, Parallel-Controlled, Evaluator-Blinded, Superiority Trial.Journal of cosmetic dermatology · 2025Trial
- Hybrid Biostimulator and Hyaluronic Acid Injectable for Tear Trough Rejuvenation.Aesthetic plastic surgery · 2026Article
- The Management of Poly-L-Lactic Acid (PLLA) Nodules: A Scoping Review and Evidence-Mapped Clinical Pathway.Cureus · 2026Review
- Xanthelasma-Like Reaction Following Poly-L-Lactic Acid Intradermal Injection Managed With Fractional Non-Ablative Lasers and Stem Cell-Derived Conditioned Media: A Case Report.Journal of cosmetic dermatology · 2026Article
- Comparative Physicochemical Characterization of Polylactic Acid-Based Dermal Fillers.Polymers · 2025Article
- Clinical Management of Poly-D,L-Lactic Acid Nodules: A Guideline With Diagnostic and Treatment Flowchart.Journal of cosmetic dermatology · 2025Article
- Evaluating Poly-D,L-Lactic Acid for Lower Eyelid Rejuvenation: Efficacy and Safety.Journal of cosmetic dermatology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoly-D,L-lactic acid (PDLLA) is used for tear trough rejuvenation but can cause complications like nodular reactions. This report describes using a radiofrequency device to manage these nodules. CASE PRESENTATION: A 42-year-old woman developed firm, non-inflammatory nodules 3 weeks after receiving PDLLA (Juvelook) injections in the tear trough area. The nodules were firm and not associated with erythema or tenderness.
interventionThe monopolar radiofrequency device was used directly on the nodules with 150 shots at an energy level 115 J, 28.75 J/cm². The treatment resulted in complete resolution of the nodules within 24 hours.
resultsThe radiofrequency treatment effectively resolved the nodular reaction without recurrence, highlighting the device's compatibility with the unique structure of Juvelook's PDLLA.
conclusionRadiofrequency therapy is effective for managing nodular reactions following PDLLA injections. Further research is needed to optimise protocols and improve the safety of biostimulator treatments in cosmetic procedures.
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