Evidence map›Paper›PMID 39282594›Full record

ArticleCurrent research in physiology2024

Glycophagy is involved in cardiac glycogen regulation in response to exercise.

Samuel L James, Parisa Koutsifeli, Randall F D'Souza, Stewart Wc Masson, Jonathan St Woodhead, Troy L Merry, Lea Md Delbridge, Kimberley M Mellor

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Article in Current research in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samuel L JamesDepartment of Physiology, University of Auckland, Auckland, New Zealand.
Parisa KoutsifeliDepartment of Physiology, University of Auckland, Auckland, New Zealand.
Randall F D'SouzaDepartment of Physiology, University of Auckland, Auckland, New Zealand.
Stewart Wc MassonDepartment of Nutrition, University of Auckland, Auckland, New Zealand.
Jonathan St WoodheadDepartment of Nutrition, University of Auckland, Auckland, New Zealand.
Troy L MerryDepartment of Nutrition, University of Auckland, Auckland, New Zealand.
Lea Md DelbridgeDepartment of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.
Kimberley M MellorDepartment of Physiology, University of Auckland, Auckland, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac glycogen-autophagy ('glycophagy') is disturbed in cardiometabolic pathologies. The physiological role of cardiac glycophagy is unclear. Exercise induces transient cardiac glycogen accumulation. Thus, this study experimentally examined glycophagy involvement during recovery from an exhaustive exercise protocol. Peak myocardial glycogen accumulation in mice was evident at 2 h post-exercise, preceded by transient activation of glycogen synthase. At 4 and 16 h post-exercise, glycogen degradation was associated with decreased STBD1 (glycophagy tagging protein) and increased GABARAPL1 (Atg8 protein), suggesting that glycophagy activity was increased. These findings provide the first evidence that glycophagy is involved in cardiac glycogen physiologic homeostasis post-exercise.

Indexed as

GAAGABARAPL1Glycogen-autophagyGlycogen phosphorylaseGlycogen synthaseSTBD1

Identifiers

PMID39282594
PMCPMC11402405

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.