Evidence map›Paper›PMID 39282431›Full record

ArticlebioRxiv : the preprint server for biology2024

Gigaxonin, mutated in Giant Axonal Neuropathy, interacts with TDP-43 and other RNA binding proteins.

Cassandra L Phillips, Maryam Faridounnia, Rachel A Battaglia, Baggio A Evangelista, Todd J Cohen, Puneet Opal, Thomas W Bouldin, Diane Armao, Natasha T Snider

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cassandra L PhillipsDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
Maryam FaridounniaDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
Rachel A BattagliaDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.
Baggio A EvangelistaDepartment of Neurology, University of North Carolina at Chapel Hill.
Todd J CohenDepartment of Neurology, University of North Carolina at Chapel Hill.
Puneet OpalDepartments of Neurology and Cell and Developmental Biology, Northwestern University, Chicago, IL.
Thomas W BouldinDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.
Diane ArmaoDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.
Natasha T SniderDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill.

Funding

Understanding the Cellular Basis of Movement DisordersR01NS082351 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Puneet Opal · 2013 to 2026
$6.2M
Elucidating cellular mechanisms underlying neurodegenerationR01NS127204 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Puneet Opal · 2022 to 2026
$2.8M
Enhancement Training for the Next Generation of Translational Ph.D. ScientistsT32GM122741 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOLBERG, ALISA S., YEH, JEN JEN · 2018 to 2022
$898k
Intermediate Filament Proteostasis and RNA regulation in Giant Axonal NeuropathyR21NS121578 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARMAO, DIANE, SNIDER, NATASHA T · 2021 to 2022
$428k
Function of reactive astrocytes in aging and neurodegenerative diseaseF99AG068523 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BATTAGLIA, RACHEL · 2020 to 2020
$31k
NIA NIH HHS F99 AG068523NIGMS NIH HHS T32 GM122741NINDS NIH HHS R01 NS082351NINDS NIH HHS R01 NS127204NINDS NIH HHS R21 NS121578
6 · The paper itself

Abstract

Giant Axonal Neuropathy (GAN) is a neurodegenerative disease caused by loss-of-function mutations in the

Identifiers

PMID39282431
PMCPMC11398400

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.