Evidence map›Paper›PMID 39282428›Full record

ArticlebioRxiv : the preprint server for biology2025

TGFβ primes alveolar-like macrophages to induce type I IFN following TLR2 activation.

Sean M Thomas, Abigail P McGee, Taryn E Vielma, Laurisa M Ankley, Alexander W Rapp, Kayla N Conner, Francois LeSage, Christopher D Tanner, Eleanor C Scheeres, Joshua J Obar and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Sean M ThomasDepartment of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI.
Abigail P McGeeDepartment of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Taryn E VielmaDepartment of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI.ORCID 0000-0003-2408-1426
Laurisa M AnkleyDepartment of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI.
Alexander W RappDepartment of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Kayla N ConnerDepartment of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI.ORCID 0000-0002-2408-6502
Francois LeSageDepartment of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Christopher D TannerDepartment of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Eleanor C ScheeresDepartment of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI.ORCID 0000-0002-7238-2496
Joshua J ObarDepartment of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH.ORCID 0000-0003-4068-7911
Andrew J OliveDepartment of Microbiology, Genetics, and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI.ORCID 0000-0003-3441-3113

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Translational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 2018 to 2026
$13.9M
IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5M
HOST-MICROBE INTERACTIONST32AI007519 · NIAID · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 1997 to 2026
$5.9M
Fungal spore sensing by MDA5 is necessary for antifungal immunity against Aspergillus fumigatusR01AI139133 · NIAID · DARTMOUTH COLLEGE · PI JOSHUA J OBAR · 2019 to 2026
$3.6M
Regulators of IFN-gamma responses during Mycobacterium tuberculosis infectionR01AI165618 · NIAID · MICHIGAN STATE UNIVERSITY · PI Andrew Olive · 2022 to 2026
$2.6M
Genetic Mechanisms of Tissue-Resident Macrophage Maintenance and Function (Supplement)R35GM146795 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Andrew Olive · 2022 to 2026
$2.0M
Dartmouth Cystic Fibrosis Training ProgramT32HL134598 · NHLBI · DARTMOUTH COLLEGE · PI George A. O'Toole · 2017 to 2026
$1.7M
Super-resolution spinning disk confocal microscope for Dartmouth Life SciencesS10OD032310 · OD · DARTMOUTH COLLEGE · PI AHMED, YASMATH · 2022 to 2022
$600k
NCI NIH HHS P30 CA023108NHLBI NIH HHS T32 HL134598NIAID NIH HHS R01 AI139133NIAID NIH HHS R01 AI165618NIAID NIH HHS T32 AI007363NIAID NIH HHS T32 AI007519NIDDK NIH HHS P30 DK117469NIGMS NIH HHS P20 GM113132NIGMS NIH HHS R35 GM146795NIH HHS S10 OD032310
6 · The paper itself

Abstract

Alveolar macrophages (AMs) are key mediators of lung function and are potential targets for therapies during respiratory infections. TGFβ is an important regulator of AM differentiation and maintenance, but how TGFβ directly modulates the innate immune responses of AMs remains unclear. This shortcoming prevents effective targeting of AMs to improve lung function in health and disease. Here we leveraged an optimized

Identifiers

PMID39282428
PMCPMC11398362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.