Evidence map›Paper›PMID 39282410›Full record

ArticlebioRxiv : the preprint server for biology2024

Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function.

Kazuya Ono, Amandine Jarysta, Natasha C Hughes, Alma Jukic, Hui Ho Vanessa Chang, Michael R Deans, Ruth Anne Eatock, Kathleen E Cullen, Katie Kindt, Basile Tarchini

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Kazuya OnoDepartment of Neurobiology, University of Chicago, Chicago, IL, 60637, USA.
Amandine JarystaThe Jackson Laboratory, Bar Harbor, ME 04609, USA.ORCID 0000-0002-9519-3559
Natasha C HughesDept. of Biomedical Engineering, Johns Hopkins University, Baltimore, 21205 MD, USA.
Alma JukicSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MA, USA.
Hui Ho Vanessa ChangDept. of Biomedical Engineering, Johns Hopkins University, Baltimore, 21205 MD, USA.
Michael R DeansDepartment of Neurobiology, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0001-6319-7945
Ruth Anne EatockDepartment of Neurobiology, University of Chicago, Chicago, IL, 60637, USA.
Kathleen E CullenDept. of Biomedical Engineering, Johns Hopkins University, Baltimore, 21205 MD, USA.ORCID 0000-0002-9348-0933
Katie KindtSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MA, USA.ORCID 0000-0002-1065-8215
Basile TarchiniThe Jackson Laboratory, Bar Harbor, ME 04609, USA.ORCID 0000-0003-2708-6273

Funding

In vivo investigation of sensory hair cell function and developmentZIADC000085 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI KINDT, KATIE · 2014 to 2025
$21.4M
Hair Cell Polarization and Sensory Bundle DevelopmentR01DC015242 · NIDCD · JACKSON LABORATORY · PI Basile Robin Tarchini · 2017 to 2026
$5.4M
Mechanism and Functional Significance of Polarity Reversal in Mechanosensory OrgansR01DC018304 · NIDCD · JACKSON LABORATORY · PI CULLEN, KATHLEEN E, EATOCK, RUTH ANNE · 2020 to 2024
$3.5M
Intramural NIH HHS ZIA DC000085NIDCD NIH HHS R01 DC015242NIDCD NIH HHS R01 DC018304
6 · The paper itself

Abstract

Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect stimuli in opposing directions. The underlying mechanism is highly conserved: the transcription factor EMX2 is regionally expressed in just one hair cell population and acts through the receptor GPR156 to reverse cell orientation relative to the other population. In mouse and zebrafish, loss of Emx2 results in sensory organs that harbor only one hair cell orientation and are not innervated properly. In zebrafish, Emx2 also confers hair cells with reduced mechanosensory properties. Here, we leverage mouse and zebrafish models lacking GPR156 to determine how detecting stimuli of opposing directions serves vestibular function, and whether GPR156 has other roles besides orienting hair cells. We find that otolith organs in

Identifiers

PMID39282410
PMCPMC11398332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.