ArticlebioRxiv : the preprint server for biology2024
Putting computational models of immunity to the test - an invited challenge to predict
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Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
59 authors.
Pramod ShindeCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0002-1071-2744
Lisa WillemsenCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Michael AndersonDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Minori AokiCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Saonli BasuDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-1200-4546
Julie G BurelCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0003-1692-2758
Peng ChengDepartment of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Souradipto Ghosh DastidarDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Aidan DunleavySchool of Statistics, University of Minnesota, Minneapolis, MN, USA.
Tal EinavCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Jamie ForschmiedtDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Slim FouratiDepartment of Medicine, Division of Allergy and Immunology, Feinberg School of Medicine and Center for Human Immunobiology, Northwestern University, Chicago, IL, USA.
Javier GarciaDepartment of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
William GibsonVaccine Research Center, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA.
Jason A GreenbaumLJI Bioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA, USA.
Leying GuanDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
Weikang GuanDepartment of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Jeremy P GygiProgram in Computational Biology & Bioinformatics, Yale University, New Haven, CT, USA.
Brendan HaLJI Bioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA, USA.
Joe HouVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jason HsiaoDepartment of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Yunda HuangVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Rick JansenBiostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Bhargob KakotyDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Zhiyu KangDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
James J KobieDepartment of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-8069-0272
Mari KojimaCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Anna KonstorumDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Jiyeun LeeCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Sloan A LewisCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Aixin LiDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Eric F LockDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Jarjapu MahitaCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Marcus MendesCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Hailong MengDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Aidan NeherDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Somayeh NiliCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Lars Rønn OlsenUniversity of Denmark, Denmark.
Shelby OrfieldCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
James A OvertonKnocean, Inc., Toronto, Canada.
Nidhi PaiDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Cokie ParkerNational Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA.
Brian QianDepartment of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Mikkel RasmussenCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Joaquin ReynaCenter for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Eve RichardsonCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Sandra SafoDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Josey SorensonDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Aparna SrinivasanDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Nicky ThruppCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Rashmi TippalagamaCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Raphael TrevizaniCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Steffen VentzDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Jiuzhou WangDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Cheng-Chang WuDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Ferhat AyDepartment of Medicine, University of California San Diego, San Diego, CA, USA.ORCID 0000-0002-0708-6914
Barry GrantDepartment of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Steven H KleinsteinProgram in Computational Biology & Bioinformatics, Yale University, New Haven, CT, USA.
Bjoern PetersCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Funding
T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitisU19AI142742 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Alessandro Sette · 2019 to 2026
$32.8MDeveloping computational models to predict the immune response to B. pertussis booster vaccinationU01AI150753 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI PETERS, BJOERN · 2020 to 2024
$7.1MStudying the function of human genetic variation in the light of 3D genome organizationR35GM128938 · NIGMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Ferhat Ay · 2018 to 2026
$4.6MIdentifying mechanisms and correlates of long-lasting vaccine-induced immunity to whooping coughU01AI141995 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI PETERS, BJOERN, SETTE, ALESSANDRO · 2019 to 2023
$4.1MNIAID NIH HHS U01 AI141995NIAID NIH HHS U01 AI150753NIAID NIH HHS U19 AI142742NIGMS NIH HHS R35 GM128938
Abstract
Systems vaccinology studies have been used to build computational models that predict individual vaccine responses and identify the factors contributing to differences in outcome. Comparing such models is challenging due to variability in study designs. To address this, we established a community resource to compare models predicting
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.