Evidence map›Paper›PMID 39282303›Full record

ArticlebioRxiv : the preprint server for biology2024

Structure and inhibition mechanisms of

Nitesh Kumar Khandelwal, Meghna Gupta, James E Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Y Eng, Tomo Kawate, Sree Ganesh Balasubramani, Andrej Sali, Deborah T Hung and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Nitesh Kumar KhandelwalDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.
Meghna GuptaDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.
James E GomezBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sulyman BarkhoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ziqiang GuanDepartment of Biochemistry, Duke University Medical Center, Durham, NC, USA.
Ashley Y EngBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Tomo KawateBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sree Ganesh BalasubramaniDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA.
Andrej SaliDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA.
Deborah T HungBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Robert M StroudDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-2083-5665

Funding

Vulnerabilities in Mycobacterial Cell-Wall BiogenesisP01AI095208 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SASSETTI, CHRISTOPHER M · 2012 to 2022
$19.8M
STRUCTURE/FUNCTION OF PROTEINS AT MOLECULAR LEVELR01GM024485 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STROUD, ROBERT M · 1985 to 2024
$7.5M
Molecular Basis for Transmembrane Conduction & SignalingR37GM024485 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STROUD, ROBERT M · 2007 to 2016
$4.7M
Roles of novel cationic lipids in bacterial pathogenesisR01AI178692 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI Kelly S Doran, Ziqiang Guan · 2023 to 2026
$2.6M
Acquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0M
Glacios™ Cryo Transmission Electron Microscope with 200 kV XFEG opticsS10OD026881 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2019 to 2019
$1.8M
Molecular Basis for Transmembrane Conduction & SignalingR35GM156263 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Robert M Stroud · 2025 to 2026
$1.2M
Linux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456k
NIAID NIH HHS P01 AI095208NIAID NIH HHS R01 AI178692NIGMS NIH HHS R01 GM024485NIGMS NIH HHS R35 GM156263NIGMS NIH HHS R37 GM024485NIH HHS S10 OD020054NIH HHS S10 OD021741NIH HHS S10 OD026881
6 · The paper itself

Abstract

A broad chemical genetics screen in

Identifiers

PMID39282303
PMCPMC11398473

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.