Evidence map›Paper›PMID 39282282›Full record

ArticlebioRxiv : the preprint server for biology2024

Molecular glues that inhibit deubiquitylase activity and inflammatory signalling.

Francesca Chandler, Poli Adi Narayana Reddy, Smita Bhutda, Rebecca L Ross, Arindam Datta, Miriam Walden, Kieran Walker, Stefano Di Donato, Joel A Cassel, Michael A Prakesch and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Francesca ChandlerAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID 0000-0003-3465-7599
Poli Adi Narayana ReddyThe Wistar Cancer Center for Molecular Screening, The Wistar Institute, Philadelphia, PA, USA.
Smita BhutdaDepartment of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rebecca L RossLeeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.ORCID 0000-0001-7750-4280
Arindam DattaDepartment of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Miriam WaldenAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Kieran WalkerLeeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
Stefano Di DonatoLeeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.ORCID 0000-0003-1256-0761
Joel A CasselThe Wistar Cancer Center for Molecular Screening, The Wistar Institute, Philadelphia, PA, USA.
Michael A PrakeschDrug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.ORCID 0000-0003-2960-6471
Ahmed AmanDrug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Alessandro DattiDepartment of Agriculture, Food, and Environmental Sciences, University of Perugia, Perugia, Italy.ORCID 0000-0001-6824-7382
Lisa J CampbellAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Martina FoglizzoAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID 0000-0001-9132-4737
Lillie BellAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Daniel N SteinDepartment of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
James R AultAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Rima S Al-AwarDrug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Antonio N CalabreseAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID 0000-0003-2437-7761
Frank SicheriCentre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.ORCID 0000-0002-9824-2117
Francesco Del GaldoLeeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.ORCID 0000-0002-8528-2283
Joseph M SalvinoThe Wistar Cancer Center for Molecular Screening, The Wistar Institute, Philadelphia, PA, USA.
Roger A GreenbergDepartment of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1326-8981
Elton ZeqirajAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID 0000-0003-0239-5926

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9M
Tumor cell instrinsic DNA damage signaling to the immune responseP01CA265794 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Roger A Greenberg · 2023 to 2026
$8.5M
The RAP80-BRCC36 Deubiquitinating Complex in DNA RepairR01CA138835 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Roger A Greenberg · 2010 to 2026
$5.2M
Purchase of an Echo 650 acoustic liquid handler with Access workstationS10OD030245 · OD · WISTAR INSTITUTE · PI SALVINO, JOSEPH M · 2021 to 2021
$567k
NCI NIH HHS P01 CA265794NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA138835NIH HHS S10 OD030245Wellcome Trust
6 · The paper itself

Abstract

Deubiquitylases (DUBs) are crucial in cell signalling and are often regulated by interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signalling by cleaving K63-linked polyubiquitin chains on Type I interferon receptors (IFNAR1). As a Zn

Identifiers

PMID39282282
PMCPMC11398498

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.