Evidence map›Paper›PMID 39282264›Full record

ArticlebioRxiv : the preprint server for biology2024

Two functional forms of the Meckel-Gruber syndrome protein TMEM67 generated by proteolytic cleavage by ADAMTS9 mediate Wnt signaling and ciliogenesis.

Manu Ahmed, Sydney Fischer, Karyn L Robert, Karen I Lange, Michael W Stuck, Sunayna Best, Colin A Johnson, Gregory J Pazour, Oliver E Blacque, Sumeda Nandadasa

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Manu AhmedDepartment of Pediatrics, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0002-2841-1624
Sydney FischerDepartment of Pediatrics, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0001-7366-7605
Karyn L RobertDepartment of Pediatrics, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0009-0006-1805-3989
Karen I LangeSchool of Biomolecular & Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland.ORCID 0000-0002-2414-5277
Michael W StuckProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0003-3387-5850
Sunayna BestDivision of Molecular Medicine, Leeds Institute of Medical Research, The University of Leeds, Leeds, UK.ORCID 0000-0002-8685-7800
Colin A JohnsonDivision of Molecular Medicine, Leeds Institute of Medical Research, The University of Leeds, Leeds, UK.
Gregory J PazourProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0002-6285-8796
Oliver E BlacqueSchool of Biomolecular & Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland.ORCID 0000-0003-1598-2695
Sumeda NandadasaDepartment of Pediatrics, University of Massachusetts Chan Medical School, Worcester, MA.ORCID 0000-0002-4954-6376

Funding

Intraflagellar Transport Proteins in MiceR01GM060992 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Gregory J Pazour · 2001 to 2026
$10.3M
Extracellular protease modulation of the cilium transition zone in kidney development and diseaseR01DK126804 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Sumeda Nandadasa · 2022 to 2026
$1.8M
Transmission Electron Microscope for Core EM FacilityS10OD025113 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENDRICKS, GREGORY · 2018 to 2018
$600k
Scanning Electron Microscope for Core EM FacilityS10RR021043 · NCRR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W · 2007 to 2007
$498k
UltramicrotomeS10OD021580 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENDRICKS, GREGORY · 2016 to 2016
$53k
NCRR NIH HHS S10 RR021043NIDDK NIH HHS R01 DK126804NIGMS NIH HHS R01 GM060992NIH HHS S10 OD021580NIH HHS S10 OD025113Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ADAMTS9CiliopathiesExtracellular matrix metalloproteinasesMeckel-Gruber syndromeROR2TMEM67Transition zone assemblyWnt signalling

Identifiers

PMID39282264
PMCPMC11398388

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.