Evidence map›Paper›PMID 39282230›Full record

ArticleBio-protocol2024

Single-Molecule Sequencing of the

Yu-Chih Tsai, Katherine A Brown, Mylinh T Bernardi, John Harting, Claire D Clelland

Abstract read
In one paragraph

Article in Bio-protocol, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Arrayed dual-gRNA CRISPR screening platform forMolecular therapy. Advances · 2026
    Article
  4. Review
  5. Long-Read Sequencing of thebioRxiv : the preprint server for biology · 2025
    Article
  6. Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Transgene Mapping in Animals: What to Choose?International journal of molecular sciences · 2025
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yu-Chih TsaiPacific Biosciences, Menlo Park, CA, USA.
Katherine A BrownWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Mylinh T BernardiGladstone Institutes, San Francisco, CA, USA.
John HartingPacific Biosciences, Menlo Park, CA, USA.
Claire D ClellandWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.

Funding

Resource Core II: In Vivo CoreU19NS132303 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI FYODOR D URNOV · 2023 to 2026
$19.7M
NRSA Training CoreTL1TR001871 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SOMSOUK, MA · 2016 to 2025
$10.1M
C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approachesR01AG072052 · NIA · J. DAVID GLADSTONE INSTITUTES · PI CONKLIN, BRUCE R · 2024 to 2025
$1.4M
CRISPR-Cas9 editing in C9orf72 patient derived iPSCK08NS112330 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CLELLAND, CLAIRE · 2020 to 2024
$1.2M
NCATS NIH HHS TL1 TR001871NIA NIH HHS R01 AG072052NINDS NIH HHS K08 NS112330NINDS NIH HHS U19 NS132303
6 · The paper itself

Abstract

A hexanucleotide GGGGCC repeat expansion in the

Indexed as

C9orf72iPSCsNo amplificationRepeat expansionSingle-molecule sequencing

Identifiers

PMID39282230
PMCPMC11393041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.