ArticleIndian journal of microbiology2024
Accuracy of Xpert Carba-R Assay for the Diagnosis of Carbapenemase-producing Organisms from Rectal Swabs in Asia: a Diagnostic Meta-analysis.
Article in Indian journal of microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The Cepheid Xpert Carba-R assay has been demonstrated to be reliable for rapid detection of carbapenemase-producing orgnisms (CPO) directly from rectal swabs but the performance of which remains unclear in Asia.We searched PubMed, EMBASE and Cochrane Library databases to identify studies according to predetermined criteria. STATA 13.0 software was used to analyze the tests for sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), area under the summary receiver operating characteristic curves (AUC). QUADAS-2 was used to assess the quality of included studies with RevMan 5.2. A total of 5 unique studies involving 10807 samples met the inclusion criteria. The pooled sensitivity, specificity, PLR, NLR, and the AUC with 95% CIs of Xpert Carba-R were 0.91 (0.72-0.97), 0.99 (0.96-1.00), 71.24 (25.41-199.73), 0.09 (0.03-0.32), 0.99 (0.98-1.00), respectively.
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