Evidence map›Paper›PMID 39282150›Full record

ArticleOxidative medicine and cellular longevity2022

Coprophagy Prevention Affects the Reproductive Performance in New Zealand White Rabbits Is Mediated through Nox4-ROS-NF

Zhichao Li, RuiTing Li, Jing Li, Zhitong Wang, Hui He, Duo Yan, Lei Yu, Hengjian Li, Ming Li, Huifen Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhichao LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID https://orcid.org/0000-0001-5448-9145
RuiTing LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID https://orcid.org/0000-0001-6295-465X
Jing LiAnimal Health Supervision Institute of Biyang, Henan 463700, China.ORCID https://orcid.org/0000-0003-4714-5525
Zhitong WangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID https://orcid.org/0000-0002-3258-3488
Hui HeCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID https://orcid.org/0000-0001-5012-494X
Duo YanCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID https://orcid.org/0000-0002-3895-9650
Lei YuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID https://orcid.org/0000-0002-5293-1339
Hengjian LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID https://orcid.org/0000-0002-5728-5989
Ming LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID https://orcid.org/0000-0002-2218-4408
Huifen XuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID https://orcid.org/0000-0003-3963-2868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coprophagy is of great significance to the growth, development, and reproductive performance of rabbits. This study is aimed at exploring the effect of coprophagy on the reproductive performance of New Zealand white rabbits by coprophagy prevention (CP). The results showed that CP treatment significantly decreased the growth and development performance of female rabbits and the live birth rate of embryos. The results of blood biochemical indexes showed that CP treatment significantly increased the contents of serum ALB, ALP, and MDA, while serum SOD activity was significantly decreased. Transcriptome analysis showed that GO terms were mainly enriched in transport function and reproductive function after CP treatment. In addition, KEGG results showed that inflammation related signal pathways were activated and the expression level of genes related to tight junction proteins was downregulated by CP treatment. Concurrently, western blot further confirmed the results of KEGG. In short, fecal feeding is an important survival strategy for some small rodents, coprophagy prevention will affect the inflammatory level of the body, change the oxidative stress level of the body, and then activate NOX4-ROS-NF-

Identifiers

PMID39282150
PMCPMC11401658

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.