Evidence map›Paper›PMID 39282130›Full record

ArticleInternational journal of health sciences

The relationship between phytoestrogen-rich supplements and breast cancer: A multicenter case-control study in Saudi Arabia.

Sahar M Alnefaie, Nawaf M Alwagdani, Rashed A Althobaiti, Khaled M Almansori, Yousef Alalawi, Eyad I Al-Kharashi, Ahmed Al-Ameer, Maha Abdel Hadi

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Article in International journal of health sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sahar M AlnefaieDepartment of Surgery, Taif University, Taif, Saudi Arabia.
Nawaf M AlwagdaniDepartment of Orthopedic Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Rashed A AlthobaitiDepartment of General Surgery, Alhada Hospital for Armed Forces, Taif, Saudi Arabia.
Khaled M AlmansoriDepartment of General Surgery, Alhada Hospital for Armed Forces, Taif, Saudi Arabia.
Yousef AlalawiDepartment of General Surgery, King Salman Hospital for Armed Forces, Tabuk, Saudi Arabia.
Eyad I Al-KharashiDepartment of General Surgery, SB-Breast and Endocrine Surgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Ahmed Al-AmeerDepartment of General Surgery, King Abdullah Hospital, Bisha, Saudi Arabia.
Maha Abdel HadiDepartment of Surgery, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The prospective effect of phytoestrogen-rich supplements has been explored by many researchers in an attempt to reduce breast cancer (BC) risk worldwide. In Saudi Arabia, some widely used supplements have high phytoestrogen content. Therefore, we aimed to (1) assess the relationship between phytoestrogen supplements (PSs) that are widely used among women of Saudi Arabia and BC and (2) assess the relationship based on the menstrual status. Methods: The study took place during 2020-2022 to assess several PSs using a case-control design that included five centers from different provinces around the country. A questionnaire was answered by the participants that included 381 (46%) cases (diagnosed with BC) and 449 (54%) controls (free of BC). The PS items were assessed individually and on the multivariant analysis model. Results: Of the 12 phytoestrogen-rich supplements, soy milk showed a significant decrease in BC risk. However, Conclusion: Soy isoflavones continue to show a significant risk reduction that could be used for a modified approach to reduce the risk of BC. However,

Indexed as

Breast cancerEchinaceagreen tealicorice rootsoy isoflavones

Identifiers

PMID39282130
PMCPMC11393387

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.