Evidence map›Paper›PMID 39282088›Full record

ArticleFrontiers in physiology2024

In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by

Jenette G Creso, Ilhan Gokhan, Michael J Rynkiewicz, William Lehman, Jeffrey R Moore, Stuart G Campbell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Evaluating Pathogenicity ofJournal of precision medicine (Amsterdam, Netherlands) · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jenette G CresoDepartment of Biomedical Engineering, Yale University, New Haven, CT, United States.
Ilhan GokhanDepartment of Biomedical Engineering, Yale University, New Haven, CT, United States.
Michael J RynkiewiczDepartment of Pharmacology, Physiology and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, United States.
William LehmanDepartment of Pharmacology, Physiology and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, United States.
Jeffrey R MooreDepartment of Biological Sciences, University of Massachusetts-Lowell, Lowell, MA, United States.
Stuart G CampbellDepartment of Biomedical Engineering, Yale University, New Haven, CT, United States.

Funding

THIN FILAMENTS AND VERTEBRATE SMOOTH MUSCLE CONTRACTIONR01HL036153 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI William J Lehman · 1986 to 2026
$6.5M
Revealing Pathomechanisms of Mutant TPM1 Through a Hybrid Computational-Experimental ApproachR01HL136590 · NHLBI · YALE UNIVERSITY · PI STUART G CAMPBELL, William J Lehman · 2017 to 2026
$5.6M
Cooperativity in the Cardiac Myofilament Interactome in Health and DiseaseR01HL123774 · NHLBI · UNIVERSITY OF MASSACHUSETTS LOWELL · PI MOORE, JEFFREY R · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL036153NHLBI NIH HHS R01 HL123774NHLBI NIH HHS R01 HL136590
6 · The paper itself

Abstract

Dilated cardiomyopathy (DCM) is an inherited disorder often leading to severe heart failure. Linkage studies in affected families have revealed hundreds of different mutations that can cause DCM, with most occurring in genes associated with the cardiac sarcomere. We have developed an investigational pipeline for discovering mechanistic genotype-phenotype relationships in DCM and here apply it to the DCM-linked tropomyosin mutation

Indexed as

computational modelingdilated cardiomyopathydisease modelingengineered heart tissuetropomyosin

Identifiers

PMID39282088
PMCPMC11392859

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.