Evidence map›Paper›PMID 39281868›Full record

ArticleResearch square2024

Behavioral regression in shank3

Rajaram Kshetri, James O Beavers, Romana Hyde, Roseline Ewa, Amber Schwertman, Sarahi Porcayo, Ben D Richardson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Rajaram KshetriDepartment of Pharmacology, Southern Illinois University - School of Medicine, Springfield, IL 62702.
James O BeaversDepartment of Pharmacology, Southern Illinois University - School of Medicine, Springfield, IL 62702.
Romana HydeDepartment of Biological Sciences, University of Idaho, Moscow, ID 83844.
Roseline EwaDepartment of Pharmacology, Southern Illinois University - School of Medicine, Springfield, IL 62702.
Amber SchwertmanDepartment of Pharmacology, Southern Illinois University - School of Medicine, Springfield, IL 62702.
Sarahi PorcayoDepartment of Pharmacology, Southern Illinois University - School of Medicine, Springfield, IL 62702.
Ben D RichardsonDepartment of Pharmacology, Southern Illinois University - School of Medicine, Springfield, IL 62702.

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Scott A Minnich · 2012 to 2026
$59.8M
Cerebellar granule cell dysfunction in Shank3 mutant miceR01MH129749 · NIMH · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI Ben D Richardson · 2022 to 2026
$1.9M
NIGMS NIH HHS P20 GM103408NIMH NIH HHS R01 MH129749
6 · The paper itself

Abstract

Background: Methods: S Results: Deletion of Limitations: Other behavioral tests of muscle strength (grip strength test), memory (Barnes/water maze), and communication (ultrasonic vocalization), were not performed. Further study is necessary to elucidate how SHANK3 modulates synaptic function at the mossy fiber-granule cell synapse in the cerebellum. Conclusions: Our findings reveal an age-related exacerbation of behavioral impairments in

Indexed as

AMPARautism spectrum disordercerebellumglutamate receptorgranule cellmouse behavior phenotypePhelan-McDermid syndromeregressionShank3

Identifiers

PMID39281868
PMCPMC11398578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.