ArticleResearch square2024
ATM phosphorylation of CD98HC increases antiporter membrane localization and prevents chronic toxic glutamate accumulation in Ataxia telangiectasia.
Alexander Bishop, July Carolina Romero, Sonal Tonapi, Manish Parihar, Eva Loranc, Henry Miller, Liesl Lawrence, Nicklas Bassani, Daniel Robledo, Lin Cao and 11 more
Abstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
21 authors.
Sonal TonapiUniversity of Texas Health at San Antonio.
Manish PariharUniversity of Texas Health at San Antonio.
Eva LorancUniversity of Texas Health at San Antonio.
Henry MillerUniversity of Texas Health at San Antonio.
Liesl LawrenceUniversity of Texas Health at San Antonio.
Nicklas BassaniUniversity of Texas Health at San Antonio.
Daniel RobledoUniversity of Texas Health at San Antonio.
Lin CaoUniversity of Texas Health at San Antonio.
Jia NieUniversity of Texas Health at San Antonio.
Kairi KandaUniversity of Texas Health at San Antonio.
Aiola StojaUniversity of Texas Health at San Antonio.
Natalia GarciaUniversity of Texas Health at San Antonio.
Aparna GorthiUniversity of Texas Health at San Antonio.
Brian StovekenUniversity of Texas Health at San Antonio.
Teresa FanCenter for Environmental and Systems Biochemistry, University of Kentucky.
Teresa CasselMarkey Cancer Center, University of Kentucky.
Nicolas MusiUniversity of California.
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MUniversity of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3MTRAINING GRANT ON THE BIOLOGY OF AGINGT32AG021890 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Erzsebet Kokovay, JAMES FLOYD NELSON · 2003 to 2026
$11.4MCancer Biology Training ProgramT32CA148724 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Pei Wang, Feng-Chun Yang · 2011 to 2026
$3.3MDysregulated transcription processes in Ewing sarcoma:R01CA241554 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BISHOP, ALEXANDER JAMES · 2020 to 2025
$2.3MNRSA Training Core (TL1)TL1TR002647 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHUN, YONG-HEE PATRICIA, FREI, CHRISTOPHER R. · 2018 to 2022
$1.8MA screen for damage response genes using recombinationK22ES012264 · NIEHS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BISHOP, ALEXANDER JAMES · 2004 to 2006
$321kThe dynamics and impact of R-loops in epigenetic stability and agingF31AG072902 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MILLER, HENRY · 2021 to 2022
$41kNCATS NIH HHS TL1 TR002647NCI NIH HHS P30 CA054174NCI NIH HHS P30 CA177558NCI NIH HHS R01 CA241554NCI NIH HHS T32 CA148724NIA NIH HHS F31 AG072902NIA NIH HHS T32 AG021890NIEHS NIH HHS K22 ES012264
6 · The paper itselfAbstract
Ataxia telangiectasia (A-T) is a rare genetic disorder characterized by neurological defects, immunodeficiency, cancer predisposition, radiosensitivity, decreased blood vessel integrity, and diabetes. ATM, the protein mutated in A-T, responds to DNA damage and oxidative stress, but its functional relationship to the progressive clinical manifestation of A-T is not understood. CD98HC chaperones cystine/glutamate (x
Identifiers
PMID39281865
PMCPMC11398575
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