Evidence map›Paper›PMID 39281851›Full record

ArticleBrain & spine2024

Is the ICP pulse waveform P2/P1 ratio during -6° head-down tilt associated with relative VO

Rafaella Mendes Zambetta, Étore De Favari Signini, Aparecida Maria Catai, Thainá Cristina Ramos Dos Santos, Eloisa Soares Michaliski, Ana Karoline Nazario, Gabriela Nagai Ocamoto, Gustavo Frigieri, Thiago Luiz Russo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain & spine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rafaella Mendes ZambettaPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, Km 235, São Carlos, SP, Brazil.
Étore De Favari SigniniPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, Km 235, São Carlos, SP, Brazil.
Aparecida Maria CataiPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, Km 235, São Carlos, SP, Brazil.
Thainá Cristina Ramos Dos SantosPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, Km 235, São Carlos, SP, Brazil.
Eloisa Soares MichaliskiPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, Km 235, São Carlos, SP, Brazil.
Ana Karoline NazarioPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, Km 235, São Carlos, SP, Brazil.
Gabriela Nagai OcamotoBrain4care Inc, São Carlos, SP, Brazil.
Gustavo FrigieriBrain4care Inc, São Carlos, SP, Brazil.
Thiago Luiz RussoPhysical Therapy Department, Federal University of São Carlos, UFSCar, Rodovia Washington Luís, Km 235, São Carlos, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Spaceflights influence intracranial compliance (ICC). P2/P1 ratio, from the intracranial pressure (ICP) waveform, provides information about ICC. Additionally, non-invasive methods for ICC monitoring are needed for spaceflights. Furthermore, astronauts try to maintain good levels of cardiorespiratory fitness before and during spaceflights, not only to sustain exploratory missions, but also to prevent diseases in extreme environments. Objective: to correlate cardiorespiratory fitness levels with the P2/P1 ratio during a microgravity analog [-6° head-down tilt (HDT)]. Method: 34 individuals (11 women), mean age of 31.7 (±6.3) years and BMI 24.2 (±3.2) performed a cardiopulmonary exercise testing (CPET) with an incremental protocol on a cycle ergometer to determine the cardiopulmonary fitness through peak relative oxygen uptake (VO Results: Volunteers presented 1.05 ± 0.2 of P2/P1 ratio and VO Conclusion: The study suggests that the better the cardiorespiratory fitness, the better ICC in a weightlessness simulation.

Indexed as

Intracranial complianceIntracranial pressurePhysical fitnessWeightlessness simulations

Identifiers

PMID39281851
PMCPMC11402318

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.