Evidence map›Paper›PMID 39281783›Full record

ArticleJournal of the Royal Statistical Society. Series A, (Statistics in Society)2024

Grace periods in comparative effectiveness studies of sustained treatments.

Kerollos Nashat Wanis, Aaron L Sarvet, Lan Wen, Jason P Block, Sheryl L Rifas-Shiman, James M Robins, Jessica G Young

Abstract read
In one paragraph

Article in Journal of the Royal Statistical Society. Series A, (Statistics in Society), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Active Monitoring versus Surgical Excision for Atypical Ductal Hyperplasia.Cancer prevention research (Philadelphia, Pa.) · 2026
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kerollos Nashat WanisDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, 677 Huntington Ave, Kresge 9th, Boston, MA, USA.ORCID https://orcid.org/0000-0003-1934-3380
Aaron L SarvetDepartment of Mathematics, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Lan WenDepartment of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada.ORCID https://orcid.org/0000-0002-6120-8492
Jason P BlockDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
James M RobinsDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, 677 Huntington Ave, Kresge 9th, Boston, MA, USA.
Jessica G YoungDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, 677 Huntington Ave, Kresge 9th, Boston, MA, USA.

Funding

Medications and Weight Gain in PCORnet: The MedWeight StudyR01DK120598 · NIDDK · HARVARD PILGRIM HEALTH CARE, INC. · PI BLOCK, JASON PERRY · 2020 to 2023
$2.9M
NIDDK NIH HHS R01 DK120598
6 · The paper itself

Abstract

Researchers are often interested in estimating the effect of sustained use of a treatment on a health outcome. However, adherence to strict treatment protocols can be challenging for individuals in practice and, when non-adherence is expected, estimates of the effect of sustained use may not be useful for decision making. As an alternative, more relaxed treatment protocols which allow for periods of time off treatment (i.e. grace periods) have been considered in pragmatic randomized trials and observational studies. In this article, we consider the interpretation, identification, and estimation of treatment strategies which include grace periods. We contrast

Identifiers

PMID39281783
PMCPMC11393553

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.