Evidence map›Paper›PMID 39281437›Full record

ArticleHeliyon2024

Screening and identification of nanobody against inhibin α-subunit from a

Jifu Ma, Bakhet Bodai, Zhongmei Ma, Kezerbek Khalembek, Jingang Xie, Rizabek Kadyken, Mukhtar Baibatshanov, Oralhazi Kazkhan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jifu MaCollege of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, 832000, China.
Bakhet BodaiCollege of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, 832000, China.
Zhongmei MaCollege of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, 832000, China.
Kezerbek KhalembekAgricultural Development Service Center of Kalabulegen Township, Fuyun County, Altay Region, Xinjiang, 836103, China.
Jingang XieCollege of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, 832000, China.
Rizabek KadykenDepartment of Production Technology of Livestock Products, Kazakh National Agrarian Research University, Almaty Province, 050010, Kazakhstan.
Mukhtar BaibatshanovDepartment of Forest Resources and Hunting, Kazakh National Agrarian Research University, Almaty Province, 050010, Kazakhstan.
Oralhazi KazkhanCollege of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, 832000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Inhibin is a member of the transforming growth factor family that influences reproduction in animals. Objective: The purpose of this study was to obtain nanobodies from the phage antibody library constructed by us that can specifically bind to inhibin α-subunit. Methods: In this study, camels were immunized with Kazakh sheep inhibin-α protein that expressed in BL21 Results: A nanobody display library was successfully constructed with a capacity of 1.05 × 10 Conclusion: Four inhibin α-subunit-specific nanobodies with biological functions were successfully screened. To the best of our knowledge, this is a new reproductive immunomodulatory pathway of inhibin α-subunit, which may change the secretion of FSH in the ovary, thus changing the estrous cycle of organisms.

Indexed as

Follicle stimulating hormoneInhibin α-subunitNanobodyPhage display

Identifiers

PMID39281437
PMCPMC11402152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.