Evidence map›Paper›PMID 39281285›Full record

ReviewFrontiers in pharmacology2024

Gastrointestinal tract organoids as novel tools in drug discovery.

Li Zhou, Dan Luo, Wei Lu, Jun Han, Maoyuan Zhao, Xueyi Li, Tao Shen, Zhao Jin, Jinhao Zeng, Yueqiang Wen

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guiding Principles: Reporting Elements for Gastrointestinal Organoid Research.Cellular and molecular gastroenterology and hepatology · 2026
    Guideline
  2. Review
  3. Review
  4. Review
  5. Biomedical applications of organoids derived from the digestive system.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Li Zhou *School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Dan Luo *School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Wei Lu *Department of Elderly Care Center, Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, China.
Jun HanSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Maoyuan ZhaoDepartment of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xueyi LiSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Tao ShenSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Zhao JinSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Jinhao ZengDepartment of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yueqiang WenSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organoids, characterized by their high physiological attributes, effectively preserve the genetic characteristics, physiological structure, and function of the simulated organs. Since the inception of small intestine organoids, other organoids for organs including the liver, lungs, stomach, and pancreas have subsequently been developed. However, a comprehensive summary and discussion of research findings on gastrointestinal tract (GIT) organoids as disease models and drug screening platforms is currently lacking. Herein, in this review, we address diseases related to GIT organoid simulation and highlight the notable advancements that have been made in drug screening and pharmacokinetics, as well as in disease research and treatment using GIT organoids. Organoids of GIT diseases, including inflammatory bowel disease, irritable bowel syndrome, necrotizing enterocolitis, and

Indexed as

disease modelingdrug discoverygastrointestinalorganoidsprecision medicine

Identifiers

PMID39281285
PMCPMC11394194

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.