Evidence map›Paper›PMID 39280840›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2024

Identification and analgesic activity study of analgesic protein Ⅶ-2 from

Yao Sun, Gen-Bao Zhang, Shu Li, Xiao-Yu Liu, Lei Chen, Peng-Ju Bao

Abstract read
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yao SunDepartment of Pathophysiology, Institute of Snake Venom, Wannan Medical College, Wuhu, China.ORCID https://orcid.org/0000-0002-9410-7815
Gen-Bao ZhangDepartment of Pathophysiology, Institute of Snake Venom, Wannan Medical College, Wuhu, China.
Shu LiDepartment of Pathophysiology, Institute of Snake Venom, Wannan Medical College, Wuhu, China.
Xiao-Yu LiuSchool of Anesthesiology, Wannan Medical College, Wuhu, China.
Lei ChenSchool of Anesthesiology, Wannan Medical College, Wuhu, China.
Peng-Ju BaoDepartment of Physiology, Institute of Snake Venom, Wannan Medical College, Wuhu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acid-sensing ion channel 1a (ASIC1a) plays a critical role in physiological and pathological processes. To further elucidate the biological functions of ASICs and their relationships with disease occurrence and development, it is advantageous to investigate and develop additional regulatory factors for ASICs. Methods: In this study, cation exchange chromatography was used to separate seven chromatographic components from Results: The purified Ⅶ-2 protein named Conclusions: The analgesic mechanism of the NNAV-Ⅶ-2 protein may be associated with its binding to ASIC1a, consequently downregulating ASIC1a expression in neural tissues.

Indexed as

Acid-sensing ion channel 1aCapillary electrophoresisNaja naja atraVenom

Identifiers

PMID39280840
PMCPMC11398835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.