Evidence map›Paper›PMID 39280771›Full record

ArticleCurrent research in neurobiology2024

Analysis of the neuromuscular deficits caused by STAM1 deficiency.

John W McLean, Mary VanHart, Madilyn P McWilliams, Charlene B Farmer, David K Crossman, Rita M Cowell, Julie A Wilson, Scott M Wilson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Junctions in Jeopardy: the neuromuscular junction is a selective pathological target in Charcot-Marie-Tooth disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John W McLeanDepartment of Neurobiology, Evelyn F. McKnight Brain Institute, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, 35294, Alabama, USA.
Mary VanHartDepartment of Neurobiology, Evelyn F. McKnight Brain Institute, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, 35294, Alabama, USA.
Madilyn P McWilliamsDepartment of Neurobiology, Evelyn F. McKnight Brain Institute, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, 35294, Alabama, USA.
Charlene B FarmerDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
David K CrossmanDepartment of Human Genetics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Rita M CowellDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Julie A WilsonDepartment of Neurobiology, Evelyn F. McKnight Brain Institute, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, 35294, Alabama, USA.
Scott M WilsonDepartment of Neurobiology, Evelyn F. McKnight Brain Institute, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, 35294, Alabama, USA.

Funding

The Role of ESCRTs in Regulating Nervous System FunctionR01NS110744 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILSON, SCOTT MICHAEL · 2020 to 2024
$1.6M
NINDS NIH HHS R01 NS110744
6 · The paper itself

Abstract

The endosomal sorting complexes required for transport (ESCRT) pathway is composed of a series of protein complexes that are essential for sorting cargo through the endosome. In neurons, the ESCRT pathway is a key mediator of many cellular pathways that regulate neuronal morphogenesis as well as synaptic growth and function. The ESCRT-0 complex, consisting of HGS (hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (signal-transducing adaptor molecule), acts as a gate keeper to this pathway, ultimately determining the fate of the endosomal cargo. We previously showed that a single nucleotide substitution in

Indexed as

EndosomeESCRT-0HGSSTAM1Synapse and NMJUbiquitin

Identifiers

PMID39280771
PMCPMC11401115

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.