ReviewCureus2024
Effect of Socialization on Alzheimer's Disease During the COVID-19 Pandemic.
Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Therapeutic Landscape of Early Symptomatic Alzheimer's Disease Translated into Everyday Practice for Geriatric Providers.Clinical interventions in aging · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age is the strongest risk factor for Alzheimer's disease, a neurodegenerative disease where beta-amyloid plaques accumulate in the brain. Elderly individuals, especially those in nursing homes, were burdened by social isolation during the COVID-19 pandemic. The purpose of this literature review is to describe the effectiveness of social engagement and how combating isolation can have a neuroprotective effect on individuals at risk for Alzheimer's disease. We conducted a search in PubMed examining articles from 2010 to 2023 that discussed the impact of socialization on Alzheimer's disease, particularly during the COVID-19 pandemic. Our search terms were "Alzheimer's Disease + Socialization," "Social Isolation + Alzheimer's Disease," "Alzheimer's Disease + COVID-19," "COVID-19 + Social Isolation," and "Social Interventions + Alzheimer's Disease." Inclusion criteria consisted of patients ages 60 and older with Alzheimer's disease, mention of social isolation or engagement, and any relationship between COVID-19 and Alzheimer's disease. Exclusion criteria were defined as other dementias, non-social interventions, and the effects of different viruses on Alzheimer's disease. After the screening process, 30 articles were included, along with six articles that were suitable to the topic. Of the 36 total articles, 19 focused on an intervention involving socialization; eight explored the effect of social isolation during COVID-19 on patients with Alzheimer's disease; five articles examined social isolation as a risk factor for dementia; and four articles discussed the effect of socialization on Alzheimer's disease. A few studies reported that having a large social network can improve cognition and mood for patients with Alzheimer's disease. Studies reported that interventions such as volunteering, video calls, group art classes, animal interactions, and others produced positive outcomes in Alzheimer's patients, but not all were statistically significant. Our review found a consistent association between a socially integrated lifestyle and a decreased incidence of early-onset dementia. Although not all interventions were solely social, a strong social structure remained at the core of a healthy aging process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.