Evidence map›Paper›PMID 39280115›Full record

ArticleTetrahedron2024

Synthesis of propargyl glycosides of

Tianyao Meng, Brady James, Jared Haymore, Rui Wang, Shawn Gubler, Seth A Taylor, M G Finn, Luc Teyton, Shenglou Deng, Paul B Savage

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tianyao MengDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Brady JamesDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Jared HaymoreDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Rui WangDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Shawn GublerDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Seth A TaylorDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
M G FinnSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Luc TeytonDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Shenglou DengDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
Paul B SavageDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.

Funding

Development of the Next Generation of Conjugate VaccinesR01AI139748 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI TEYTON, LUC · 2018 to 2021
$3.4M
NIAID NIH HHS R01 AI139748
6 · The paper itself

Abstract

We developed a method for making immune responses to bacterial glycans T cell-dependent, which involves attachment of short, synthetic glycans to a virus-like nanoparticle (VLP). This strategy enhances immune responses to glycans by facilitating cognate T cell help of B cells, leading to antibody class switching and affinity maturation yielding high-affinity, anti-glycan antibodies. This method requires synthesis of bacterial glycans as propargyl glycosides for covalent attachment to VLPs, and the resulting short linker between the VLP and glycan is important for optimal T cell receptor recognition. In this work, glycans that are part of the capsular polysaccharides (CPS) produced by

Indexed as

Bacterial glycansCapsular polysaccharidesPropargyl glycosidesStreptococcus pneumoniaeSynthetic glycans

Identifiers

PMID39280115
PMCPMC11391900

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.