Evidence map›Paper›PMID 39280063›Full record

ArticleWellcome open research2023

Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.

Sara M Willems, Natasha H J Ng, Juan Fernandez, Rebecca S Fine, Eleanor Wheeler, Jennifer Wessel, Hidetoshi Kitajima, Gaelle Marenne, Xueling Sim, Hanieh Yaghootkar and 232 more

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Article in Wellcome open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

242 authors.

Sara M Willems *MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.ORCID https://orcid.org/0000-0002-6803-3007
Natasha H J Ng *Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.
Juan FernandezWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Rebecca S FineDepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
Eleanor WheelerMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Jennifer WesselBroad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Hidetoshi KitajimaWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Gaelle MarenneDepartment of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Xueling SimSaw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, 117549, Singapore.
Hanieh YaghootkarGenetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
Shuai WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Sai ChenDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Yuning ChenDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.ORCID https://orcid.org/0000-0001-5526-1070
Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.ORCID https://orcid.org/0000-0003-0650-1351
Tibor V VargaDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-205 02, Sweden.
Jennifer L AsimitDepartment of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.ORCID https://orcid.org/0000-0002-4857-2249
Shuang FengDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Rona J StrawbridgeMental Health and Wellbeing, School of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8RZ, UK.ORCID https://orcid.org/0000-0001-8506-3585
Erica L KleinbrinkQuantitative Life Sciences, McGill University, Montreal, Quebec, Canada.
Tarunveer S AhluwaliaCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Ping AnDepartment of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, 63108, USA.ORCID https://orcid.org/0000-0001-6162-8780
Emil V AppelNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Dan E ArkingMcKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Juha AuvinenCenter for Life Course Health Research, University of Oulu, Oulu, 90014, Finland.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Nathan A BihlmeyerMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jette Bork-JensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Jennifer A BrodyCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID https://orcid.org/0000-0003-0198-5078
Audrey Y ChuDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Gail DaviesCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Ayse DemirkanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.
James S FloydCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Stefan GustafssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 75237, Sweden.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Johanna JakobsdottirIcelandic Heart Association, Kopavogur, Iceland.
Marjo-Riitta JärvelinCenter for Life Course Health Research, University of Oulu, Oulu, 90014, Finland.
Richard A JensenCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Sirkka Keinanen-KiukaanniemiFaculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.
Man LiDivision of Nephrology, Internal Medicine, School of Medicine, University of Utah, Salt Lake City, USA.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Alisa K ManningCenter for Human Genetics Research, Massachusetts General Hospital, Boston, MA, 02114, USA.
Jonathan MartenMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Karina MeidtnerDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Taulant MukaDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.
Giorgio PistisItalian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.
Bram PrinsDepartment of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Kenneth M RiceCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.
Serena SannaItalian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.ORCID https://orcid.org/0000-0002-3768-1749
Albert Vernon SmithIcelandic Heart Association, Kopavogur, Iceland.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Lorraine SouthamWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Heather M StringhamDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID https://orcid.org/0000-0002-2991-6392
Vinicius TraganteDepartment of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, 3584CX, The Netherlands.ORCID https://orcid.org/0000-0002-8223-8957
Sander W van der LaanCentral Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Helen R WarrenWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Andrianos M YiorkasSection of Investigative Medicine, Department of Medicine, Imperial College London, London, W12 0NN, UK.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.
Heather M HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.ORCID https://orcid.org/0000-0002-3583-8239
Anne E JusticeDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.
Eirini MarouliWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0001-6179-1609
Carolina Medina-GomezDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.
Saima AfaqDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK.
Wesam A AlhejilyWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.
Folkert W AsselbergsAmsterdam University Medical Centers, Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands.
Lori L BonnycastleCenter for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA.
Michiel L BotsCenter for Circulatory Health, University Medical Center Utrecht, Utrecht, 3508GA, The Netherlands.
Ivan BrandslundDepartment of Clinical Biochemistry, Lillebaelt Hospital Vejle, Vejle, 7100, Denmark.
Ji ChenDepartment of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
John DaneshDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, CB18RN, UK.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.
Tapani EbelingOulu University Hospital, Oulu, 90220, Finland.
Paul ElliottDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK.ORCID https://orcid.org/0000-0002-7511-5684
EPIC-Interact Consortium
Aliki-Eleni FarmakiDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Paul W FranksDivision of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, 02115, USA.
Steve FranksInstitute of Reproductive and Developmental Biology, Imperial College London, London, W12 0NN, UK.
Andreas FritscheGerman Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.
Anette P GjesingNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Mark O GoodarziDivision of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID https://orcid.org/0000-0001-5696-0084
Göran HallmansDepartment of Biobank Research, Umeå University, Umeå, SE-901 87, Sweden.
Tamara B HarrisIcelandic Heart Association, Kopavogur, Iceland.
Karl-Heinz HerzigInstitute of Biomedicine and Biocenter of Oulu, Faculty of Medicine, Medical Research Center Oulu and Oulu University Hospital, Oulu, Finland.
Marie-France HivertDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Torben JørgensenCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark.
Marit E JørgensenSteno Diabetes Center Copenhagen, Gentofte, 2820, Denmark.
Pekka JousilahtiDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.ORCID https://orcid.org/0000-0001-7190-0979
Eero KajantieDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Maria KaraleftheriEchinos Medical Centre, Echinos, Greece.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Leena KinnunenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Heikki A KoistinenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Pirjo KomulainenFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Peter KovacsIntegrated Research and Treatment (IFB) Center Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland.
Leslie A LangeDepartment of Medicine, Division of Bioinformatics and Personalized Medicine, University of Colorado Denver, Denver, CO, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.ORCID https://orcid.org/0000-0002-3238-7612
Aaron LeongDivision of General Internal Medicine, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA.
Jaana LindströmDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Jocelyn E Manning FoxAlberta Diabetes Institute IsletCore, University of Alberta, Edmonton, T6G 2E1, Canada.ORCID https://orcid.org/0000-0002-4157-2094
Satu MännistöDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Nisa M MaruthurDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Leena MoilanenKuopio University Hospital, Kuopio, 70210, Finland.
Antonella MulasItalian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.ORCID https://orcid.org/0000-0002-6856-1483
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, 20892, USA.
Matthew NevilleOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA.
Alison PattieDepartment of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Eva R B PetersenDepartment of Clinical Biochemistry, Lillebaelt Hospital Vejle, Vejle, 7100, Denmark.
Hannu PuolijokiSouth Ostobothnia Central Hospital, Seinajoki, 60220, Finland.
Asif RasheedCenter for Non-Communicable Diseases, Karachi, Pakistan.
Paul RedmondDepartment of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Frida RenströmDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-205 02, Sweden.
Michael RodenGerman Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.ORCID https://orcid.org/0000-0001-8200-6382
Danish SaleheenCenter for Non-Communicable Diseases, Karachi, Pakistan.
Juha SaltevoCentral Finland Central Hospital, Jyvaskyla, 40620, Finland.
Kai SavonenFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Sylvain SebertBiocenter Oulu, University of Oulu, Oulu, Finland.
Tea SkaabyCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark.
Kerrin S SmallDepartment of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.ORCID https://orcid.org/0000-0003-4566-0005
Alena StančákováInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland.
Jakob StokholmCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
E-Shyong TaiSaw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, 117549, Singapore.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.ORCID https://orcid.org/0000-0002-2756-4370
Betina H ThuesenCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark.
Anke TönjesDepartment of Medicine, University of Leipzig, Leipzig, 04103, Germany.
Emmanouil TsafantakisAnogia Medical Centre, Anogia, Greece.
Tiinamaija TuomiFolkhälsan Research Centre, Helsinki, Finland.
Jaakko TuomilehtoDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Understanding Society Scientific Group
Matti UusitupaDepartment of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70210, Finland.
Marja VääräsmäkiPEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Ilonca VaartjesCenter for Circulatory Health, University Medical Center Utrecht, Utrecht, 3508GA, The Netherlands.
Magdalena ZoledziewskaItalian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.
Goncalo AbecasisCenter for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Beverley BalkauINSERM U1018, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Villejuif, France.
Hans BisgaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Alexandra I BlakemoreSection of Investigative Medicine, Department of Medicine, Imperial College London, London, W12 0NN, UK.
Matthias BlüherDepartment of Medicine, University of Leipzig, Leipzig, 04103, Germany.
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, 14558, Germany.
Eric BoerwinkleThe Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, 77030, USA.
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA.
Mark J CaulfieldWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
John C ChambersDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.
Francis S CollinsCenter for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, 20892, USA.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Francesco CuccaItalian National Research Council, Institute of Genetics and Biomedic Research, Cittadella Universitaria, Monserrato, 09042, Italy.
Gert J de BorstDepartment of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.ORCID https://orcid.org/0000-0002-1733-263X
George DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Hester M den RuijterExperimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Ele FerranniniCNR Institute of Clinical Physiology, Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.
Harald GrallertGerman Center for Diabetes Research (DZD), München-Neuherberg, 85764, Germany.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.ORCID https://orcid.org/0000-0001-8748-3831
Andrew T HattersleyUniversity of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID https://orcid.org/0000-0002-9405-9550
Joel N HirschhornDivision of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, 02115, USA.
Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.
Erik IngelssonDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.ORCID https://orcid.org/0000-0002-2751-1770
Kay-Tee KawDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID https://orcid.org/0000-0002-8802-2903
Wieland KiessPediatric Research Center, Department of Women & Child Health, University of Leipzig, Leipzig, Germany.
Jaspal S KoonerEaling Hospital, London North West Healthcare NHS Trust, Middlesex, UB1 3HW, UK.
Antje KörnerPediatric Research Center, Department of Women & Child Health, University of Leipzig, Leipzig, Germany.
Timo LakkaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.ORCID https://orcid.org/0000-0002-5017-7344
Lars LindDepartment of Medical Sciences, Molecular Epidemiology; EpiHealth, Uppsala University, Uppsala, 75185, Sweden.
Cecilia M LindgrenWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Allan LinnebergCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark.ORCID https://orcid.org/0000-0002-0994-0184
Leonard LipovichCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, 48201-1928, USA.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Jun LiuDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.
Yongmei LiuDepartment of Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC, 27157, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA.ORCID https://orcid.org/0000-0002-8532-5087
Patrick E MacDonaldAlberta Diabetes Institute IsletCore, University of Alberta, Edmonton, T6G 2E1, Canada.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
Andrew D MorrisUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH16 4UX, UK.
Patricia B MunroeWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Alison MurrayAberdeen Biomedical Imaging Centre, University of Aberdeen, Foresterhill Health Campus, Aberdeen, AB25 2ZD, UK.ORCID https://orcid.org/0000-0003-4915-4847
Sandosh PadmanabhanBritish Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.ORCID https://orcid.org/0000-0003-3869-5808
Colin N A PalmerDivision of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, DD2 4BF, UK.
Gerard PasterkampExperimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Ozren PolasekFaculty of Medicine, University of Split, Split, Croatia.
David PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID https://orcid.org/0000-0003-1249-6106
Michael A ProvinceDepartment of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, 63108, USA.
Bruce M PsatyCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Olov RolandssonDepartment of Public Health & Clinical Medicine, Section for Family Medicine, Umeå University, Umeå, SE-901 85, Sweden.
Patrik RorsmanOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Igor RudanUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH16 4UX, UK.
Veikko SalomaaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FI-00271, Finland.ORCID https://orcid.org/0000-0001-7563-5324
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.
Robert SladekDepartment of Medicine, McGill University, Montreal, Quebec, H4A 3J1, Canada.
Blair H SmithDivision of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, DD2 4BF, UK.ORCID https://orcid.org/0000-0002-5362-9430
Timothy D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Michael StumvollDepartment of Medicine, University of Leipzig, Leipzig, 04103, Germany.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands.ORCID https://orcid.org/0000-0002-2374-9204
Mark WalkerInstitute of Cellular Medicine, The Medical School, Newcastle University, Newcastle, NE2 4HH, UK.
Nick J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.ORCID https://orcid.org/0000-0003-1422-2993
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.
Eleftheria ZegginiDepartment of Human Genetics, Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Andrew P MorrisCentre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Jose C FlorezDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Mark I McCarthyOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.
James B MeigsDivision of General Internal Medicine, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA.
Anubha MahajanWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Anna L GloynOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.ORCID https://orcid.org/0000-0003-1205-1844
Inês BarrosoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.ORCID https://orcid.org/0000-0001-5800-4520

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
Building on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Cell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1M
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6 · The paper itself

Abstract

Background: Genome-wide association studies for glycemic traits have identified hundreds of loci associated with these biomarkers of glucose homeostasis. Despite this success, the challenge remains to link variant associations to genes, and underlying biological pathways. Methods: To identify coding variant associations which may pinpoint effector genes at both novel and previously established genome-wide association loci, we performed meta-analyses of exome-array studies for four glycemic traits: glycated hemoglobin (HbA1c, up to 144,060 participants), fasting glucose (FG, up to 129,665 participants), fasting insulin (FI, up to 104,140) and 2hr glucose post-oral glucose challenge (2hGlu, up to 57,878). In addition, we performed network and pathway analyses. Results: Single-variant and gene-based association analyses identified coding variant associations at more than 60 genes, which when combined with other datasets may be useful to nominate effector genes. Network and pathway analyses identified pathways related to insulin secretion, zinc transport and fatty acid metabolism. HbA1c associations were strongly enriched in pathways related to blood cell biology. Conclusions: Our results provided novel glycemic trait associations and highlighted pathways implicated in glycemic regulation. Exome-array summary statistic results are being made available to the scientific community to enable further discoveries.

Indexed as

effector genesexome chipgenetic discoveryglycaemic traitssummary statistics resources

Identifiers

PMID39280063
PMCPMC11399760

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