ArticleFrontiers in endocrinology2024
Association between nontraditional lipid parameters and the risk of type 2 diabetes and prediabetes in patients with nonalcoholic fatty liver disease: from the national health and nutrition examination survey 2017-2020.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- m1A Epitranscriptomic Control of NUPR1 by YTHDF1 Exacerbates Metabolic Dysregulation in Nonalcoholic Fatty Liver Disease.Journal of clinical and translational hepatology · 2026Article
- Atherogenic index of plasma as a simple marker for NAFLD risk stratification in community-dwelling older adults: a cross-sectional study with incremental predictive value assessment.Frontiers in endocrinology · 2026Article
- Lipid metabolism-MAFLD crosstalk: mechanisms and therapy.Frontiers in endocrinology · 2026Review
- Diabetes and NAFLD: A Synergistic Threat to Metabolic Health.Advanced pharmaceutical bulletin · 2025Review
- Mitochondrial dysfunction, a new marker warning of neuropsychiatric disorder risk: evidence from genetics and epidemiology.Annals of general psychiatry · 2025Article
- Association between AIP and incident T2DM in patients with NAFLD: a retrospective study.BMC endocrine disorders · 2025Article
- Cholesterol-HDL-glucose index and type 2 diabetes risk in middle-aged and older adults: Evidence from a nationwide Chinese cohort.Medicine · 2025Observational
- Atherogenic index of plasma and its 5-year changes associated with type 2 diabetes risk: a 10-Year cohort study.Cardiovascular diabetology · 2025Article
- Association between atherogenic index of plasma and type 2 diabetes in women with a history of gestational diabetes mellitus: a cross-sectional study.Diabetology & metabolic syndrome · 2025Article
- Association of non-traditional lipid indices with diabetes and insulin resistance in US adults: mediating effects of HOMA-IR and evidence from a national cohort.Clinical and experimental medicine · 2025Article
- Multi-Omics Analysis Reveals Causal Relationships and Potential Mediators Between Dietary Preferences and Risk of NAFLD.Food science & nutrition · 2025Article
- Association between atherogenicity indices and prediabetes: a 5-year retrospective cohort study in a general Chinese physical examination population.Cardiovascular diabetology · 2025Article
- Predictive Effect of FT3 Within the Euthyroid Range on HDL-C in Patients With Type 2 Diabetes: A Cross-Sectional Analysis of Inpatients in China.Journal of clinical laboratory analysis · 2025Article
- Association of Smoking and Alcohol with Abdominal Aortic Calcification in the General Middle-Aged and Elderly Populations.Reviews in cardiovascular medicine · 2025Article
- Cardiac metabolic index as a predictor of new-onset diabetes in non-alcoholic fatty liver disease patients: a longitudinal cohort analysis.BMC endocrine disorders · 2025Article
- Establishment and evaluation of a novel practical tool for the screening of metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus.Frontiers in nutrition · 2025Article
- Relationship between nontraditional lipid parameters and the risk of type 2 diabetes in individuals recovered from dyslipidemia: a cohort study.Frontiers in endocrinology · 2025Article
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8 authors.
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Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder strongly linked to type 2 diabetes mellitus (T2DM). Understanding the predictive value of lipid parameters in identifying abnormal glucose metabolism in NAFLD patients is crucial for early intervention. Methods: This study analyzed data from the National Health and Nutrition Examination Survey(NHANES) database (2017-2020) involving 1066 NAFLD patients. Participants were categorized into three groups: T2DM (n=414), prediabetes mellitus (pre-DM) (n=507), and normoglycemia (NG) (n=145). Traditional lipid parameters [triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C)] and nontraditional lipid parameters [atherogenic index of plasma (AIP), residual cholesterol (RC), and non-high-density lipoprotein cholesterol (non-HDL-C)] were evaluated for their association with T2DM and pre-DM. Results: Elevated TG levels were significantly associated with an increased risk of T2DM and pre-DM, whereas high HDL-C demonstrated a protective effect. Among nontraditional lipid parameters, increased AIP and RC were most strongly associated with T2DM risk, while high non-HDL-C was best associated with the development of pre-DM. Stratified analyses revealed that these associations were stronger in younger, non-obese, smoking, and female NAFLD patients. Conclusion: Nontraditional lipid parameters, particularly AIP and RC, show superior predictive value over traditional lipid parameters in identifying abnormal glucose metabolism in NAFLD patients. Incorporating these novel biomarkers into clinical practice could enhance early detection and prevention strategies for T2DM and pre-DM in this high-risk population.
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