ArticleJournal of gastrointestinal oncology2024
Identification of a lactylation-related gene signature to characterize subtypes of hepatocellular carcinoma using bulk sequencing data.
Article in Journal of gastrointestinal oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Integrating epidemiological and transcriptomic data reveals novel lipid metabolic drivers of obstructive sleep apnea.Nutrition & metabolism · 2026Article
- Icaritin eliminates tumor-associated macrophages via STX16-dependent extracellular vesicle delivery of autophagosomes from hepatocellular carcinoma cells.Journal of experimental & clinical cancer research : CR · 2026Article
- Mechanisms of lactylation modification in hepatocellular carcinoma treatment resistance.Gastroenterology report · 2026Review
- The lactylation axis: bridging metabolic reprogramming and immunosuppression in the tumor microenvironment.Frontiers in immunology · 2026Review
- Lysine lactylation in neutrophil functional remodeling across diverse disease contexts.Frontiers in immunology · 2026Review
- Lactylation and macrophage polarization from a clinical perspective: pathological mechanisms and therapeutic potential.Frontiers in immunology · 2026Review
- Exploring the mechanisms of mutual influence between lactylation and macrophage polarization in the context of disease.Clinical and translational medicine · 2025Review
- Construction of lactylation-related prognostic signature for glioma.Discover oncology · 2025Article
- Path towards personalized care of hepatocellular carcinoma: a nomogram for survival prediction.Journal of gastrointestinal oncology · 2025Article
- Exploring lactylation and cancer biology: insights from pathogenesis to clinical applications.Frontiers in cell and developmental biology · 2025Review
- The role of lactylation in tumor growth and cancer progression.Frontiers in oncology · 2025Review
- Review
- Lactate-induced protein lactylation in cancer: functions, biomarkers and immunotherapy strategies.Frontiers in immunology · 2024Review
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Authors and funding
8 authors.
Funding
Abstract
Background: Prior studies indicate that lactylation regulates various biological mechanisms within cancer. However, lactylation-related genes (LRGs) have been found to have limited value in predicting the prognosis of hepatocellular carcinoma (HCC). The aim of this study was to review HCC LRGs using data from The Cancer Genome Atlas (TCGA). Methods: The RNA sequencing data and related clinical information of patients with HCC patients were collected from the TCGA database. A total of 20 LRGs were selected and bioinformatics analysis was performed. A consistency cluster analysis was conducted to classify the HCC tumors. Using a lactylation-related model of HCC, prognosis, immune cell infiltration, and immunotherapy was evaluated. Results: A total of 4,378 genes were associated with prognosis. Twenty LRGs (i.e., Conclusions: Strong correlation between LRGs and tumor classification as well as immunity in patients with HCC was identified. LRG signatures serve as reliable prognostic markers for HCC.
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