ArticleJournal of the Royal Statistical Society. Series B, Statistical methodology2024
GENIUS-MAWII: for robust Mendelian randomization with many weak invalid instruments.
Article in Journal of the Royal Statistical Society. Series B, Statistical methodology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- FA-MFMR: a multivariable functional Mendelian randomization method that accounts for correlated longitudinal exposures via factor augmentation.Bioinformatics (Oxford, England) · 2026Article
- Mendelian Randomization Methods for Causal Inference: Estimands, Identification and Inference.Statistics in medicine · 2026Review
- Efficient Mendelian randomization analysis with self-adaptive determination of sample structure and multiple pleiotropic effects.American journal of human genetics · 2025Article
- Causal association of antibody-mediated immune responses to infectious disease agents with lung cancer: a Mendelian randomization study.Discover oncology · 2025Article
- Causal Relationship Between Diet, Lipids, Immune Cells, and Chronic Fatigue Syndrome: A Two-Mediation Mendelian Randomization Study.Food science & nutrition · 2025Article
- A focusing framework for testing bi-directional causal effects in Mendelian randomization.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2025Article
- Identification and Inference with Invalid Instruments.Annual review of statistics and its application · 2025Article
- A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases.Journal of obesity & metabolic syndrome · 2025Review
- Best-subset instrumental variable selection method using mixed integer optimization with applications to health-related quality of life and education-wage analyses.Research square · 2024Article
- Benchmarking Mendelian randomization methods for causal inference using genome-wide association study summary statistics.American journal of human genetics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Mendelian randomization (MR) addresses causal questions using genetic variants as instrumental variables. We propose a new MR method, G-Estimation under No Interaction with Unmeasured Selection (GENIUS)-MAny Weak Invalid IV, which simultaneously addresses the 2 salient challenges in MR: many weak instruments and widespread horizontal pleiotropy. Similar to MR-GENIUS, we use heteroscedasticity of the exposure to identify the treatment effect. We derive influence functions of the treatment effect, and then we construct a continuous updating estimator and establish its asymptotic properties under a many weak invalid instruments asymptotic regime by developing novel semiparametric theory. We also provide a measure of weak identification, an overidentification test, and a graphical diagnostic tool.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.