Evidence map›Paper›PMID 39279663›Full record

ArticleAlcohol, clinical & experimental research2024

Alcohol and fear conditioning produce strain-specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice.

Laurel R Seemiller, Lisa R Goldberg, Aswathy Sebastian, Sue Rutherford Siegel, Craig Praul, Dana Zeid, Istvan Albert, Jacob Beierle, Camron D Bryant, Thomas J Gould

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In one paragraph

Article in Alcohol, clinical & experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. High-Fat Diet Alters Behavior and Hippocampal Gene Expression.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laurel R SeemillerDepartment of Biobehavioral Health, Penn State University, University Park, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-1534-5357
Lisa R GoldbergDepartment of Biobehavioral Health, Penn State University, University Park, Pennsylvania, USA.
Aswathy SebastianHuck Institutes of the Life Sciences, Penn State University, University Park, Pennsylvania, USA.
Sue Rutherford SiegelDepartment of Biobehavioral Health, Penn State University, University Park, Pennsylvania, USA.
Craig PraulHuck Institutes of the Life Sciences, Penn State University, University Park, Pennsylvania, USA.
Dana ZeidDepartment of Biobehavioral Health, Penn State University, University Park, Pennsylvania, USA.
Istvan AlbertDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, USA.
Jacob BeierleDepartment of Pharmacology, Boston University School of Medicine, Boston, Massachusetts, USA.
Camron D BryantDepartment of Pharmaceutical Sciences, Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Thomas J GouldDepartment of Biobehavioral Health, Penn State University, University Park, Pennsylvania, USA.

Funding

Neurobehavioral Mechanisms of Choices to Smoke Cannabis in Cannabis Use DisorderR01DA044339 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BEDI, GILLINDER I., EVANS, SUZETTE M · 2017 to 2021
$3.1M
Research Training in Physiological Adaptations to StressT32GM108563 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, KORZICK, DONNA HOPE · 2014 to 2023
$2.2M
Gene Variants for Nicotine Withdrawal Deficits in LearningU01DA041632 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI GOULD, THOMAS J · 2016 to 2020
$1.8M
NIDA NIH HHS R01 DA044339NIDA NIH HHS U01 DA041632NIDA NIH HHS U01DA041632NIDA NIH HHS U01DA044339NIGMS NIH HHS T32 GM108563NIGMS NIH HHS T32GM108563Pennsylvania State University
6 · The paper itself

Abstract

backgroundAdolescent sensitivity to alcohol is influenced by genetic background. Data from our laboratory suggested that adolescent C57BL/6J and DBA/2J inbred mice differed in susceptibility to alcohol-induced deficits in dorsal hippocampus-dependent contextual fear learning.

methodsTo investigate the biological underpinnings of this strain difference, we examined dorsal hippocampus gene expression using RNA-sequencing after alcohol or saline administration followed by Pavlovian fear conditioning across male and female C57BL/6J and DBA/2J adolescents.

resultsStrains exhibited dramatic differences in dorsal hippocampus gene expression. Specifically, C57BL/6J and DBA/2J strains differed by 3526 transcripts in males and 2675 transcripts in females. We identified pathways likely to be involved in mediating alcohol's effects on learning, including networks associated with Chrna7, a gene encoding the nicotinic cholinergic receptor alpha 7 subunit, and Fmr1, a gene encoding the fragile X messenger ribonucleoprotein.

conclusionsThese findings provide insight into the mechanisms underlying strain differences in alcohol's effects on learning and suggest that different biological networks are recruited for learning based on genetics, sex, and alcohol exposure.

Indexed as

alcoholfear conditioninggeneticshippocampusRNA

Identifiers

PMID39279663
PMCPMC12667965

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.