Evidence map›Paper›PMID 39279555›Full record

ArticleChemical communications (Cambridge, England)2024

Fluorogenic chemical tools to shed light on CES1-mediated adverse drug interactions.

Carolyn J Karns, Taylor P Spidle, Emmanuel Adusah, Mingze Gao, Jennifer E Nehls, Michael W Beck

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carolyn J KarnsDepartment of Biological Sciences, Eastern Illinois University, Charleston, IL 61920, USA.ORCID 0000-0002-6926-9142
Taylor P SpidleDepartment of Biological Sciences, Eastern Illinois University, Charleston, IL 61920, USA.ORCID 0000-0001-6313-4805
Emmanuel AdusahDepartment of Chemistry and Biochemistry, Eastern Illinois University, Charleston, IL 61920, USA. MBeck2@EIU.edu.ORCID 0009-0005-9992-1436
Mingze GaoDepartment of Biological Sciences, Eastern Illinois University, Charleston, IL 61920, USA.ORCID 0000-0001-7196-8471
Jennifer E NehlsDepartment of Biological Sciences, Eastern Illinois University, Charleston, IL 61920, USA.ORCID 0009-0004-2748-2385
Michael W BeckDepartment of Chemistry and Biochemistry, Eastern Illinois University, Charleston, IL 61920, USA. MBeck2@EIU.edu.ORCID 0000-0002-1737-0951

Funding

Chemical biology approaches to understand interindividual variability in carboxylesterase activityR15GM152890 · NIGMS · EASTERN ILLINOIS UNIVERSITY · PI BECK, MICHAEL WILLIAM · 2024 to 2024
$355k
NIGMS NIH HHS R15 GM152890
6 · The paper itself

Abstract

Studying factors that cause interindividual variability of carboxylesterase 1 (CES1) activity is currently difficult due to limited methods. Here, fluorogenic tools for measuring CES1 activity are developed and demonstrated to report on these factors in living cells. These tools enable experiments that will develop a deeper understanding of CES1 metabolism.

Indexed as

Carboxylic Ester HydrolasesFluorescent DyesDrug InteractionsHumansMolecular StructureCarboxylic Ester HydrolasesCES1 protein, humanFluorescent Dyes

Identifiers

PMID39279555
PMCPMC11496031

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.